Trials with Poly A:Poly U as Adjuvant Therapy Complementing Surgery in Randomized Patients with Breast Cancer
The experimental basis for this trial was discussed by Fanny Lacour, in this volume (Chapter 9). Poly A:poly U, when given after surgery, was found to have a definite inhibitory effect on tumor growth, at least in the case of spontaneous mammary adenocarcinoma in mice and transplantable melanoma in hamsters. As used, this complex had neither toxic nor enhancing effects. Moreover, when poly A:poly U was administered to newborn C3H/He mice, it had a prophylactic effect, and the tumor incidence was significantly lower in the treated group than among the controls.
KeywordsBreast Cancer Murine Spleen Cell Pyrogenic Effect Pyrogenicity Test Mouse Toxicity
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