Abstract
In recent years it has become increasingly evident that the cell surface membrane plays a crucial role in almost all cellular activities and is, thus, of great importance in defense against neoplastic disease. Changes in the structure of the cell membrane are of particular interest because alterations in the properties of the cell surface are believed to contribute to the disordered proliferations that characterize malignant cells. Human histocompatibility (HL-A) antigens have proved to be a particularly useful tool in studying these changes on the cell membrane, since these genetically segregating antigenic components are present on the surface of all nucleated cells. These individuality markers can readily be defined since grafts exchanged between individuals who differ with respect to these antigens are promptly rejected by the immune system of the recipient. Furthermore, the association of some HL-A antigens with susceptibility to neoplastic disease has given an additional impetus to the characterization of these cell surface markers at the cellular and molecular levels in order to acquire a better understanding of the allograft rejection phenomenon and to gain further insight into the pathogenesis of the neoplastic process.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Basilico, C. and Marin, G. Susceptibility of cells in different stages of the mitotic cycle to transformation by polyoma virus. Virology, 28:429, 1966.
Bertram, J. S. and Heidelberger, C. Cell cycle dependency of oncogenic transformation induced by N-methyl-N’-nitronitrosoguanidine in culture. Cancer Res., 34:526, 1974.
Buell, D. M. and Fahey, J. L. Limited periods of gene expression in immunoglobulin synthesizing cells. Science, 164:1524, 1969.
Cikes, M. Relationship between growth rate, cell volume, cell cycle kinetic and antigenic properties of cultured murine lymphoma cells. J. Nat. Cancer Inst., 45:979, 1970.
Cikes, M. Expression of surface antigens on cultured tumor cells in relation to cell cycle. Transplant. Proa, 3:1161, 1971.
Cooper, N. R., Polley, M. J., and Oldstone, M. B. A. Failure of terminal complement components to induce lysis of Moloney virus transformed lymphocytes. J. Immunol., 112:866, 1974.
Ferrone, S., Cooper, N. R., Pellegrino, M. A., and Reisfeld, R. A. The lymphocytotoxic reation: The mechanism of rabbit complement action. J. Immunol., 107:939, 1971.
Ferrone, S., Cooper, N. R., Pellegrino, M. A., and Reisfeld, R. A. Interaction of histocompatibility (HL-A) antibodies and complement with synchronized human lymphoid cells in continuous culture. J. Exp. Med., 137:55, 1973.
Ferrone, S., Pellegrino, M. A., Dierich, M. P., and Resifeld, R. A. Expression of histocompatibility antigens during the growth cycle of cultured lymphoid cells. In Koprowski, H., ed., Current Topics in Microbiology and Immunology. New York, Springer-Verlag, 1974, Vol. 66, p. 1.
Götze, D., Pellegrino, M. A., Ferrone, S., and Reisfeld, R. A. Expression of H-2 antigen, during growth of cultured tumor cells. Immunol. Comm., 1:533, 1972.
Karb, K. and Goldstein, G. Combination autoradiography and membrane fluorescence in studying cell cycle transplantation antigen relationship. Transplantation 11:569, 1971.
Lerner, R. A., Oldstone, M. B. A., and Cooper, N. R. Cell cycle-dependent immune lysis of Moloney virus-transformed lymphocytes: Presence of viral antigen, accessibility to antibody and complement activation. Proc. Natl. Acad. Sci. USA, 68:2584, 1971.
Pellegrino, M. A., Ferronc, S., Natali, P., Pellegrino, A., and Reisfeld, R. A. Expression of HL-A antigens in synchronized cultures of human lymphocytes. J. Immunol., 108:573, 1972.
Pellegrino, M. A., Ferrone, S., and Pellegrino, A. A simple microabsorption technique for HL-A typing. Proc. Soc. Exp. Biol. Med., 139:484, 1972.
Pellegrino, M. A., Ferrone, S., Pellegrino, A., and Reisfeld, R. A. The expression of HL-A antigens during the growth cycle of cultured human lymphoid cells. Clin. Immunol. Immunopathol., 1:182, 1973.
Pellegrino, M. A., Ferrone, S., Cooper, N. R., Dierich, M. P., and Reisfeld, R. A. Variation in susceptibility of a human lymphoid cell line to immune lysis during the cell cycle: Lack of correlation with antigen density and complement binding. J. Exp. Med., 140:578, 1974.
Reisfeld, R. A. and Kahan, B. D. The molecular nature of IIL-A antigens. In Kahan, B. D. and Reisfeld, R. A., eds. Chemical Markers of Biological Individuality: The Transplantation Antigens. New York, Academic Press, 1972, pp. 489–501.
Reisfeld, R. A., Ferrone, S., and Pellegrino, M. A. Isolation and serological evaluation of HL-A antigens solubilized from cultured human lymphoid cells. In Korn, E. D., ed. Methods in Membrane Biology. New York, Plenum Press, 1974, Vol. 1, pp. 143–92.
Takahashi, M., Yagi, Y., Morre, G. E., and Pressman, D. Immunoglobulin production in synchronized cultures of human hematopoietic cell lines. J. Immunol., 103:834, 1969.
Warren, L. and Glick, M. D. Membranes of animal cells. II. The metabolism and turnover of the surface membrane. J. Cell. Biol., 37:729, 1968.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Reisfeld, R.A., Pellegrino, M.A., Ferrone, S., Oh, S. (1975). Expression of HL-A Antigens on Lymphoblastoid Cells. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-66112-9_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66114-3
Online ISBN: 978-3-642-66112-9
eBook Packages: Springer Book Archive