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On the Evidence for Type-C RNA Tumor Virus Information and Virus-Related Reverse Transcriptase in Animals and in Human Leukemia Cells

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Fundamental Aspects of Neoplasia

Abstract

RNA tumor viruses obtained from animals or from cultured animal cells can be divided into two categories, “endogenous’’ and “exogenous.’’ Endogenous RNA tumor viruses can be obtained from ostensibly normal (uninfected) cells or animals, some have been shown to be vertically transmitted (parent to progeny via the germ line), and those viruses that have been tested contain RNA that is closely related in nucleotide sequence to the genes of normal animals of the species that generated the virus. It has not been convincingly demonstrated that endogenous viruses induce neoplasia in animals, nor that they transform cells in culture. Exogenous viruses, obtained from virus-producing tumor tissue, are not closely related in nucleotide sequence to the genes of normal host cells and do induce neoplasia in recipient animals.

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Authors
  1. D. Gillespie
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  2. R. E. Gallagher
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  3. R. G. Smith
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  4. W. C. Saxinger
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  5. R. C. Gallo
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Editor information

Editors and Affiliations

  1. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, 70112, USA

    A. Arthur Gottlieb M.D. (Professor and Chairman) (Professor and Chairman)

  2. Institute of Microbiology, Rutgers University, New Brunswick, New Jersey, 08903, USA

    Otto J. Plescia Ph.D. (Professor of Immunochemistry) (Professor of Immunochemistry)

  3. The Medical Center, University of Alabama, Birmingham, Alabama, USA

    David H. L. Bishop Ph.D. (Professor of Microbiology) (Professor of Microbiology)

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© 1975 Springer-Verlag New York Inc.

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Gillespie, D., Gallagher, R.E., Smith, R.G., Saxinger, W.C., Gallo, R.C. (1975). On the Evidence for Type-C RNA Tumor Virus Information and Virus-Related Reverse Transcriptase in Animals and in Human Leukemia Cells. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-66112-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66114-3

  • Online ISBN: 978-3-642-66112-9

  • eBook Packages: Springer Book Archive

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