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Cytokine Knockouts

  • Book
  • © 2003
  • Latest edition

Overview

Editors:
  1. Giamila Fantuzzi

    1. University of Colorado Health Sciences Center, Denver, USA

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Part of the book series: Contemporary Immunology (CONTIM)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xix
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  2. Cytokine Knockouts in Models of Human Disease

    1. Front Matter

      Pages 1-1
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    2. Cytokine Knockouts in Inflammation

      • Pietro Ghezzi
      Pages 3-10

    3. The Use of Cytokine Knockouts to Study Host Defense Against Infection

      • Charles A. Dinarello
      Pages 11-31

    4. The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease

      • Alfons Billiau, Hubertine Heremans, Patrick Matthys
      Pages 33-55

    5. The Use of Cytokine Knockout Mice in Cancer Research

      • Robert H. Wiltrout, Jon M. Wigginton, William J. Murphy
      Pages 57-71

    6. The Use of Cytokine Knockout Mice in Neuroimmunology

      • Giamal N. Luheshi, Emmanuel Pinteaux, Hervé Boutin
      Pages 73-92

  3. Cytokine Knockout Mice

    1. Front Matter

      Pages 93-93
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    2. The Role of IL-1 in the Immune System

      • Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane et al.
      Pages 95-109

    3. IL-1 Receptor Antagonist-Deficient Mice

      • Martin J. H. Nicklin, Joanna Shepherd
      Pages 111-134

    4. A Unique Role for IL-2 in Self-Tolerance

      • Thomas Hünig, Anneliese Schimpl
      Pages 135-149

    5. Molecular Basis for Binding Multiple Cytokines by γc

      • Ferenc Olosz, Thomas R. Malek
      Pages 151-170

    6. G-CSF, GM-CSF, and IL-3 Knockout Mice

      • Thomas Enzler, Glenn Dranoff
      Pages 171-186

    7. IL-4 Knockout Mice

      • Pascale Kropf, Ingrid Müller
      Pages 187-202

    8. Role of IL-5 in Immune and Pathological Responses in the Mouse

      • Paul S. Foster, Simon P. Hogan
      Pages 203-211

    9. IL-6 Knockout Mice

      • Valeria Poli, Diego Maritano
      Pages 213-235

    10. IL-10 and IL-2 Knockout Mice

      • Karen L. Madsen, Humberto Jijon
      Pages 237-251

    11. IL-12-Deficient Mice

      • Luciano Adorini
      Pages 253-268

    12. IL-13 and Double IL-4/IL-13 Knockout Mice

      • Duncan R. Hewett, Andrew N. J. McKenzie
      Pages 269-280

    13. IL-15

      • Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, Mary K. Kennedy
      Pages 281-301
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Keywords

About this book

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Reviews

Foreword by Scott K. Durum
Reviews of the first edition:
...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne
". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal

"...essential reading for...laboratory scientists, including immunologists, developmental and cell biologists, and experimental pathologists..."
-Modern Pathology

"...a very nice compendium of research in a very important area...should be on the shelves of all life science/biomedical libraries."
-Doody's Health Sciences Book Review Journal

"This remarkable book is a powerful source of information and ideas."
-Annales de Biologie Clinique

Editors and Affiliations

  • University of Colorado Health Sciences Center, Denver, USA

    Giamila Fantuzzi

Bibliographic Information

  • Book Title: Cytokine Knockouts

  • Editors: Giamila Fantuzzi

  • Series Title: Contemporary Immunology

  • DOI: https://doi.org/10.1007/978-1-59259-405-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-58829-194-3Published: 30 July 2003

  • Softcover ISBN: 978-1-61737-415-9Published: 09 November 2010

  • eBook ISBN: 978-1-59259-405-4Published: 30 July 2003

  • Edition Number: 2

  • Number of Pages: XIX, 471

  • Number of Illustrations: 29 b/w illustrations

  • Topics: Immunology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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