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IL-6 Knockout Mice

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Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Summary

Interleukin-6 (IL-6) is a pleiotropic cytokine thought to play important regulatory roles in immunity, hemopoiesis, and inflammation (reviewed in ref. 1). The generation of IL-6-deficient mice by gene targeting has allowed direct testing of its role in a variety of physiological and pathological conditions. Thus, IL-6 has been shown to favour the resolution of infections and to promote optimal humoral responses to various antigens while at the same time being required for the development of immune-mediated diseases, such as CIA or EAE, as well as of diseases such as osteoporosis and plasmacytomas, caused by improper expansion of specific hematopietic compartments. In addition, IL-6-deficient mice display defective liver acute phase and regenerative responses, improper body weight regulation, impaired neuronal regeneration, and altered nociceptive responses, confirming the pleiotropic nature of this cytokine. This chapter attempts to review the ample literature in the field by trying to rationalize the main conclusions achieved and to highlight the open-ended problems.

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Authors
  1. Valeria Poli
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  2. Diego Maritano
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Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Giamila Fantuzzi PhD

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Poli, V., Maritano, D. (2003). IL-6 Knockout Mice. In: Fantuzzi, G. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-405-4_13

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  • DOI: https://doi.org/10.1007/978-1-59259-405-4_13

  • Publisher Name: Humana Press, Totowa, NJ

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