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IL-12-Deficient Mice

  • Chapter
Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Summary

Interleukin 12 (IL-12) is a heterodimeric cytokine composed of two covalently linked chains, p35 and p40, produced primarily by antigen-presenting cells, which plays a key role in promoting type l T helper cell (Thl) responses. The powerful activity of IL-12 requires a tight control, which is exerted at different levels. The primary control is exerted on IL-12 production by antigen-presenting cells, a major factor driving the response toward the Thl or Th2 phenotype. Another level of control regulates expression of the IL-12 receptor (R), which is composed of two subunits, β1 and β2. The IL-12Rβ2 subunit has signal-transducing capacity, and modulation of its expression is central to the control of IL-12 responsiveness. Endogenous IL-12 plays an important role in the host defence against infection by a variety of intracellular pathogens. Its Thl-promoting activity, however, also favors Thl-mediated immunopathology and, in particular, the induction of Thl-mediated autoimmune diseases. Both aspects of IL-12 activity have been extensively studied using IL-12-deficient mice, providing important information about the multifaceted role of this critical regulatory cytokine.

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Authors
  1. Luciano Adorini
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Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Giamila Fantuzzi PhD

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© 2003 Springer Science+Business Media New York

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Adorini, L. (2003). IL-12-Deficient Mice. In: Fantuzzi, G. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-405-4_15

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  • DOI: https://doi.org/10.1007/978-1-59259-405-4_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-415-9

  • Online ISBN: 978-1-59259-405-4

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