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Bleomycin: Chemical, Biochemical, and Biological Aspects

Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978

  • Sidney M. Hect

Table of contents

  1. Front Matter
    Pages N1-xi
  2. Status Reports

    1. Sidney M. Hect
      Pages 1-23
    2. Hamao Umezawa
      Pages 24-36
    3. Tomahisa Takita
      Pages 37-47
  3. Synthetic and Biosynthetic Studies

    1. Sidney M. Hecht, Donald J. Burlett, Yoshitaka Mushika, Yasuhisa. Kuroda, Mark D. Levin
      Pages 48-62
    2. Yoji Umezawa, Hajime Morishima, Takeo Yosioka, Masami Otsuka, Masaji Ohno
      Pages 63-74
  4. Physical and Spectral Analysis of Bleomycin

    1. Yasuhiko Muraoka
      Pages 92-105
    2. Hiroshi Naganawa
      Pages 106-123
  5. Bleomycin as a Metal Chelator

    1. Norman J. Oppenheimer
      Pages 124-136
    2. J. C. Dabrowiak, F. T. Greenway, F. S. Santillo
      Pages 137-155
  6. Interaction of Bleomycin with DNA

    1. Susan B. Horwitz, Edward A. Sausville, Jack Peisach
      Pages 170-183
    2. Makoto Hori
      Pages 195-206
    3. Masaru Takeshita, Arthur P. Grollman
      Pages 207-221
    4. Charles W. Haidle, R. Stephen Lloyd, Donald L. Robberson
      Pages 222-243
    5. Franklin Hutchinson, Lawrence F. Povirk
      Pages 255-266
  7. Biological Effects of Bleomycin

  8. Practical Methods for the Manipulation and Assay of Bleomycin

  9. Erratum to: Status Reports

    1. Sidney M. Hect
      Pages 352-352
  10. Erratum to: Bleomycin as a Metal Chelator

    1. J.C. Dabrowiak, F.T. Greenway, F.s. Santillo
      Pages 353-353
  11. Erratum to: Interaction of Bleomycin with DNA

    1. Masaru Takeshita, Arthur P. Grollman
      Pages 354-354
  12. Back Matter
    Pages 349-351

About this book

Introduction

This book records the proceedings of a joint U.S.-Japan symposium on the chem­ istry, biochemistry, and biology of bleomycin, an antitumor antibiotic shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin's lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretation of the scientific presentations at the meeting has been prepared by the editor and is included as the first contribution in this volume. In addition to the symposium contributions, an experimental section has been included at the end of the book dealing with practical methods for the fractiona­ tion, modification, and assay of bleomycin. It is hoped that this section will facilitate progress in this area of scientific endeavor. The symposium from which this book is derived was organized by Drs. Umezawa, Takita, and Hecht and supported financially by the National Science Foundation, the National Cancer Institute, and the Japan Society for the Promotion of Science. S. M. Hecht v Contents Status Reports Summary of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin Studies. H. UMEZAWA ................... , 24 Review of the Structural Studies on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . Synthetic and Biosynthetic Studies Studies on the Total Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... 48 A Synthetic Approach to the Pyrimidine Moiety of Bleomycin.

Keywords

Bleomycin Pyrimidine biochemistry biology cancer cell chemistry synthesis

Editors and affiliations

  • Sidney M. Hect
    • 1
  1. 1.Department of ChemistryMassachusetts Institute of TechnologyCambridgeUSA

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