Abstract
Several practical rewards may be expected to derive from the development of a workable total synthesis of bleomycin. In addition to permitting the direct verification of the proposed structure (which has been revised during this meeting by Dr. Umezawa and his co-workers) and hopefully extending the repertoire of available synthetic techniques, bleomycins of modified structure should facilitate the study of the mechanism of action of the drug and thus help to defme the structures of analogs that may have improved anticancer activity. More extensive structural modification might also afford bleomycin analogs that are useful, e.g., as tumor radioimaging agents or for coadministration with bleomycin to reduce serious side effects of the drug such as pulmonary toxicity.
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Hecht, S.M., Burlett, D.J., Mushika, Y., Kuroda, Y., Levin, M.D. (1979). Studies on the Total Synthesis of Bleomycin. In: Hect, S.M. (eds) Bleomycin: Chemical, Biochemical, and Biological Aspects. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6191-9_4
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DOI: https://doi.org/10.1007/978-1-4612-6191-9_4
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