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Bleomycin: Chemical, Biochemical, and Biological Aspects pp 37–47Cite as

Review of the Structural Studies on Bleomycin

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Abstract

More than 12 years have passed since we started our structural study of bleomycin (BLM). These studies are summarized in this chapter. BLM was isolated as a mixture of more than 10 components from the culture filtrate of Streptomyces verticillus. These were separated by CM-Sephadex column chromatography(1) and found to be different from one another in their terminal amine moieties(2). BLMs thus isolated were blue-colored equimolar copper complexes. BLM has not yet been crystallized, so that we could not utilize X-ray crystallographic analysis. In the initial stages of our structural studies, we used exclusively metal-free BLM A2, the main component of the natural BLMs. Metal-free BLM was prepared by treatment of the copper complex with hydrogen sulfide in methanolic solution.

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Authors
  1. Tomahisa Takita
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Editors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Mass., 02139, USA

    Sidney M. Hect

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© 1979 Springer-Verlag New York Inc.

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Takita, T. (1979). Review of the Structural Studies on Bleomycin. In: Hect, S.M. (eds) Bleomycin: Chemical, Biochemical, and Biological Aspects. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6191-9_3

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  • DOI: https://doi.org/10.1007/978-1-4612-6191-9_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6193-3

  • Online ISBN: 978-1-4612-6191-9

  • eBook Packages: Springer Book Archive

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