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Biological Reactive Intermediates V

Basic Mechanistic Research in Toxicology and Human Risk Assessment

  • Robert Snyder
  • I. Glenn Sipes
  • David J. Jollow
  • Terrence J. Monks
  • James J. Kocsis
  • George F. Kalf
  • Helmut Greim
  • Charlotte M. Witmer

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Table of contents

  1. Session IX

    1. J. Robert Buchanan, Christopher J. Portier
      Pages 429-437
    2. S. Langouet, B. Coles, F. Morel, K. Maheo, B. Ketterer, A. Guillouzo
      Pages 439-442
    3. Thomas G. Schulz, Diether Neubert, Donald S. Davies, Robert J. Edwards
      Pages 443-446
    4. O. Sepai, G. Sabbioni
      Pages 451-455
  2. Back Matter
    Pages 457-461

About this book

Introduction

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi­ cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Keywords

Oxidation biochemistry cytochrome P450 dopamine enzymes metabolism neurotoxicity proteins

Editors and affiliations

  • Robert Snyder
    • 1
  • I. Glenn Sipes
    • 2
  • David J. Jollow
    • 3
  • Terrence J. Monks
    • 4
  • James J. Kocsis
    • 5
  • George F. Kalf
    • 5
  • Helmut Greim
    • 6
  • Charlotte M. Witmer
    • 1
  1. 1.Environmental and Occupational Health Sciences InstituteRutgers UniversityPiscatawayUSA
  2. 2.University of ArizonaTusconUSA
  3. 3.Medical University of South CarolinaCharlestonUSA
  4. 4.University of TexasAustinUSA
  5. 5.Thomas Jefferson UniversityPhiladelphiaUSA
  6. 6.GSF Institute of ToxicologyTechnical UniversityMunichGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-9480-9
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9482-3
  • Online ISBN 978-1-4757-9480-9
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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