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Biological Reactive Intermediates V pp 253–257Cite as

Studies on the Formation of Hepatic DNA Adducts by the Antiandrogenic and Gestagenic Drug, Cyproterone Acetate

1. Adduct Levels in Various Species Including Man and 2. Persistence and Accumulation in the Rat

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 387))

Abstract

Cyproterone acetate (CPA) [Fig. 1] is a sex steroid with strong antiandrogenic and gestagenic action, which is widely used in human therapy. Upon long term feeding CPA causes liver tumors in rats [1]; this activity has been attributed to tumor promotion. The safety of the therapeutic use of the steroid has been questioned recently, since findings from our laboratories indicate that CPA exhibits genotoxic activity. CPA induces DNA repair synthesis in cultured hepatocytes from female rats [2] and the formation of CPA-derived DNA adducts in rat liver and in hepatocytes [3].

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References

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Author information

Authors and Affiliations

  1. Institut für Toxikologie, GSF-Forschungszentrum für Umwelt und Gesundheit, D-85764, Oberschleißheim, Germany

    S. Werner, S. Kunz, L. R. Schwarz & T. Wolff

  2. Regional Hygiene Institute of Central Bohemia, Videnska 1083, 14220, Prague 4, Czech Republic

    J. Topinka

  3. Chirurgische Klinik u. Polyklinik, Technischen Universität München, Germany

    T. Beckurts & C.-D. Heidecke

Authors
  1. S. Werner
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  2. J. Topinka
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  3. S. Kunz
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  4. T. Beckurts
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  5. C.-D. Heidecke
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  6. L. R. Schwarz
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  7. T. Wolff
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Editor information

Editors and Affiliations

  1. Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey, USA

    Robert Snyder  & Charlotte M. Witmer  & 

  2. University of Arizona, Tuscon, Arizona, USA

    I. Glenn Sipes

  3. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  4. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  5. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    James J. Kocsis  & George F. Kalf  & 

  6. GSF Institute of Toxicology, Technical University, Munich, Germany

    Helmut Greim

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© 1996 Springer Science+Business Media New York

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Werner, S. et al. (1996). Studies on the Formation of Hepatic DNA Adducts by the Antiandrogenic and Gestagenic Drug, Cyproterone Acetate. In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_33

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  • DOI: https://doi.org/10.1007/978-1-4757-9480-9_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9482-3

  • Online ISBN: 978-1-4757-9480-9

  • eBook Packages: Springer Book Archive

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