Reactive Intermediates of Xenobiotics in Thyroid
The formation of reactive intermediates from xenobiotics in thyroid and their potential toxic effects on the organ have received only very little attention up to now. At first glance this appears surprising, as numerous chemicals have been shown to be capable of inducing thyroid tumours in experimental animals. The lack of interest in the fate of these chemicals in thyroid is largely the consequence of the current theory of thyroid follicular cell carcinogenesis which centers on perturbations of the hormonal regulatory system which are caused by many thyroid carcinogens (Hill et al. 1989, Thomas and Williams 1991).
KeywordsThyroid Hormone Thyroid Tumour Follicular Cell Sulfinic Acid Thyroid Hormone Synthesis
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- Andrae, U., and Greim, H., 1992, Initiation and promotion in thyroid carcinogenesis. In “Tissue-specific Toxicity: Biochemical Mechanisms” (eds. W. Dekant and H.-G. Neumann), pp. 71-93, Academic Press.Google Scholar
- DeSerres, F.J., and Ashby, J., 1981, Evaluation of short-term tests for carcinogens. Report of the international collaborative program, Progr. Mutat. Res. 1, Elsevier, Amsterdam.Google Scholar
- Eling, T.E., Petry, T.W., Hughes, M.F., and Krauss, R.S., 1988, Aromatic amine metabolism catalyzed by prostaglandin H synthase. In “Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes” (eds. CM. King et al.), pp. 161–172, Elsevier, New York.Google Scholar
- IARC, 1974, IARC Monographs on the evaluation of carcinogenic risk of chemicals to man. Some antithyroid and related substances, nitrofurans and industrial chemicals, Vol.7, WHO, IARC, Lyon, France.Google Scholar
- IARC, 1987, IARC Monographs on the evaluation of carcinogenic risks to humans, Supplement 7, WHO, IARC, Lyon, France.Google Scholar
- Innes, J.R.M., Ulland, B.M., Valerio, M.G., Petrucelli, L., Fishbein, L., Hart, E.R., Pallotta, A.J., Bates, R.R., Falk, H.L., Gart, J.J., Klein, M, Mitchell, I., and Peters, J. 1969, Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: A preliminary note, J. Natl. Cancer Inst. 42: 1101–1114.PubMedGoogle Scholar
- Martelli, A., Mattioli, F., Fazio, S., Andrae, U., and Brambilla, G., 1995, DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate, Carcinogenesis (in press).Google Scholar
- NTP, 1992, National Toxicology Program: NTP technical report on the perinatal toxicology and carcinogenesis studies of ethylene thiourea (CAS No. 96-45-7) in F334/N rats and B6C3F1 mice (feed studies). NTP technical report Series No. 388. NIH Publication No. 92-2843. U.S. Department of Health and Human Services 1992.Google Scholar
- Vesselinovich, S.D., 1983, Perinatal hepatocarcinogenesis. Biol. Res. Pregnancy Perinatology 4: 22–25.Google Scholar
- Ziegler, D.M., 1980, Microsomal flavin-containing monooxygenase: oxygenation of nucleophilic nitrogen and sulfur compounds. In “Enzymatic Basis of Detoxication” (ed. W.B. Jakoby), vol.1, pp. 201–227, Academic Press, New York.Google Scholar
- Ziegler-Skylakakis, K., and Andrae, U. 1990, Genotoxicity of formamidine sulfinate, a metabolite of thiourea, in V79 cells, Mutat. Res. 234: 409–410.Google Scholar