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Biological Reactive Intermediates V pp 213–219Cite as

Reactive Intermediates of Xenobiotics in Thyroid

Formation and Biological Consequences

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 387))

Abstract

The formation of reactive intermediates from xenobiotics in thyroid and their potential toxic effects on the organ have received only very little attention up to now. At first glance this appears surprising, as numerous chemicals have been shown to be capable of inducing thyroid tumours in experimental animals. The lack of interest in the fate of these chemicals in thyroid is largely the consequence of the current theory of thyroid follicular cell carcinogenesis which centers on perturbations of the hormonal regulatory system which are caused by many thyroid carcinogens (Hill et al. 1989, Thomas and Williams 1991).

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Author information

Authors and Affiliations

  1. Institut für Toxikologie, Neuherberg, GSF-Forschungszentrum für Umwelt und Gesundheit, D-85764, Oberschleissheim, Germany

    U. Andrae

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  1. U. Andrae
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Editor information

Editors and Affiliations

  1. Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey, USA

    Robert Snyder  & Charlotte M. Witmer  & 

  2. University of Arizona, Tuscon, Arizona, USA

    I. Glenn Sipes

  3. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  4. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  5. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    James J. Kocsis  & George F. Kalf  & 

  6. GSF Institute of Toxicology, Technical University, Munich, Germany

    Helmut Greim

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© 1996 Springer Science+Business Media New York

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Andrae, U. (1996). Reactive Intermediates of Xenobiotics in Thyroid. In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_29

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  • DOI: https://doi.org/10.1007/978-1-4757-9480-9_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9482-3

  • Online ISBN: 978-1-4757-9480-9

  • eBook Packages: Springer Book Archive

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