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Acyl Glucuronides

Covalent Binding and Its Potential Relevance

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Biological Reactive Intermediates V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 387))

Abstract

In general, phase-II metabolites of drugs, such as sulfates, O- or N-glucuronides, were anticipated to be rapidly excreted into urine and bile without exhibiting significant biological/pharmacological activity. However, a few years ago various conjugates were proven to have considerable affinity to pharmacological receptors or to contribute to toxic effects. Today, it is largely accepted that they may be active and/or reactive [Kroemer and Klotz, 1992; Spahn-Langguth and Benet, 1992a, b].

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Authors and Affiliations

  1. Department of Pharmacology, Johann Wolfgang Goethe-University Frankfurt/M. Biocenter Niederursel, Marie-Curie-Straße 9 Geb. N260, D-60439, Frankfurt/M, Germany

    Hildegard Spahn-Langguth Ph.D. (Assoc. Professor, Pharmaceutics), Monika Dahms & Andreas Hermening

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  1. Hildegard Spahn-Langguth Ph.D.
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  2. Monika Dahms
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  3. Andreas Hermening
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Editors and Affiliations

  1. Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey, USA

    Robert Snyder  & Charlotte M. Witmer  & 

  2. University of Arizona, Tuscon, Arizona, USA

    I. Glenn Sipes

  3. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  4. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  5. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    James J. Kocsis  & George F. Kalf  & 

  6. GSF Institute of Toxicology, Technical University, Munich, Germany

    Helmut Greim

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Spahn-Langguth, H., Dahms, M., Hermening, A. (1996). Acyl Glucuronides. In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_39

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  • DOI: https://doi.org/10.1007/978-1-4757-9480-9_39

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