Acyl Glucuronides

Covalent Binding and Its Potential Relevance
  • Hildegard Spahn-Langguth
  • Monika Dahms
  • Andreas Hermening
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


In general, phase-II metabolites of drugs, such as sulfates, O- or N-glucuronides, were anticipated to be rapidly excreted into urine and bile without exhibiting significant biological/pharmacological activity. However, a few years ago various conjugates were proven to have considerable affinity to pharmacological receptors or to contribute to toxic effects. Today, it is largely accepted that they may be active and/or reactive [Kroemer and Klotz, 1992; Spahn-Langguth and Benet, 1992a, b].


Human Serum Albumin Glucuronic Acid Covalent Binding Acyl Migration Clofibric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Hildegard Spahn-Langguth
    • 1
  • Monika Dahms
    • 1
  • Andreas Hermening
    • 1
  1. 1.Department of PharmacologyJohann Wolfgang Goethe-University Frankfurt/M. Biocenter NiederurselFrankfurt/MGermany

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