Inhibition of Cytochrome P450 Enzymes by Nitric Oxide

  • J. Stadler
  • W. A. Schmalix
  • J. Doehmer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


Inflammatory Stimulation of the liver causes significant alterations in liver cell metabolism. Recent experimental studies indicate that induction of nitric oxide (NO) biosynthesis may play a major role in the regulation of inflammatory processes and subsequent metabolic changes (23). Under cell culture conditions bacterial toxins and proinflammatory cytokines, such as TNFα, IL-1 and IFNγ, were identified as inducers of NO biosynthesis in parenchymal as well as non-parenchymal liver cells (6). Hepatic NO biosynthesis was also demonstrated in several animal models for local or systemic inflammation including injection of Corynebacterium parvum or lipopolysaccharides (4, 10). Finally, human hepatocytes were shown to express inducible nitric oxide synthase (iNOS) activity, which set the basis for cloning and heterologous expression of the human iNOS gene (24, 11). These findings support the idea that NO biosynthesis of the liver is a clinically relevant phenomenon in diseases characterized by local or systemic inflammatory reactions.


Nitric Oxide Nitric Oxide Electron Paramagnetic Resonance Electron Paramagnetic Resonance Signal Human Hepatocyte 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • J. Stadler
    • 1
  • W. A. Schmalix
    • 2
  • J. Doehmer
    • 2
  1. 1.Chirurgische Klinik und PoliklinikTechnische Universität MünchenMünchenGermany
  2. 2.Institut für Toxikologie und UmwelthygieneTechnische Universität MünchenMünchenGermany

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