Overview
- Covers all approaches for vascular tissue engineering
- Provides frequent updates in the fast growing field of regenerative medicine
- Authors are key opinion leaders in their field
Part of the book series: Reference Series in Biomedical Engineering (RSBE)
Part of the book sub series: Tissue Engineering and Regeneration (TIENRE)
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Table of contents (19 entries)
Keywords
About this book
Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery.
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Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. Â All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications.
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The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment.
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Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Editors and Affiliations
About the editors
Beat H. Walpoth, MD, PD, FAHA, is a trained cardiovascular surgeon, past Director of Cardiovascular Research in the Department of Surgery at Geneva University Hospital, Switzerland. He obtained his medical degree in 1972 at Zurich University, followed by Board of Surgery (including thoracic and cardiovascular) in 1982. Postgraduate training included two years at the Peter Bent Brigham, a Harvard university hospital, Boston (1973-75) and cardiac transplantation at Stanford University (1982-84). Teaching appointments were held at Harvard Medical School, Universities of Bern and Geneva (Emeritus) and still ongoing in Verona University (Visiting Professor). Dr. Walpoth is a recipient of several national and international awards, including the European Society for Artificial Organs (ESAO) Wichtig Award in the years 2008 and 2012 for his group’s research on Vascular Tissue Engineering.  He has over 150 publications, of which more than 50 are first-author papers, in peer reviewedjournals. Past-president of the ESAO; organizer of the Annual Congresses of the ESAO in 2000 in Lausanne, and 2008 in Geneva. He has also been responsible for the bi-annual Swiss Experimental Surgery Symposium (2006, 2008, 2010, 2012 and 2016). As from 2004 he is a member of the International Faculty for Artificial Organs and the Director of the Internationally Co-tutored PhD Course in Biotechnology and Bioengineering (Universities of Geneva and Verona) since 2005. Currently, he holds the presidency of the International Symposium on Vascular Tissue Engineering (ISVTE) and has created the TERMIS Thematic Group on Vascular Tissue Engineering. His current main areas of interest include vascular tissue engineering and bio-artificial cardiovascular support.
Bibliographic Information
Book Title: Tissue-Engineered Vascular Grafts
Editors: Beat Walpoth, Helga Bergmeister, Gary Bowlin, Deling Kong, Joris Rotmans, Peter Zilla
Series Title: Reference Series in Biomedical Engineering
DOI: https://doi.org/10.1007/978-3-319-71530-8
Publisher: Springer Cham
eBook Packages: Springer Reference Engineering, Reference Module Computer Science and Engineering
eBook ISBN: 978-3-319-71530-8Due: 06 August 2019
Series ISSN: 2731-0493
Series E-ISSN: 2731-0507
Topics: Biomedical Engineering and Bioengineering, Regenerative Medicine/Tissue Engineering, Vascular Surgery, Biomaterials
Industry Sectors: Aerospace, Biotechnology, Consumer Packaged Goods, Electronics, Energy, Utilities & Environment, Engineering, IT & Software, Materials & Steel, Oil, Gas & Geosciences, Pharma