Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications

Schoen, F. J.; Fioretta, E. S.; Mallone, A.; Smits, A. I. P. M.; Klouda, L.; Bouten, C. V. C.

doi:10.1007/978-3-319-71530-8_15-1

F. J. Schoen⁷,
E. S. Fioretta⁸,
A. Mallone⁸,
A. I. P. M. Smits⁹,
L. Klouda⁹ &
…
C. V. C. Bouten⁹

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

264 Accesses

Abstract

Clinical translation of vascular tissue engineering is hampered by inconsistencies in graft outcomes. In this chapter, we argue that variation in graft outcomes is largely due to our lack of fully understanding vascular regeneration and remodeling in response to specific graft properties. In addition, results obtained from animal studies are difficult to translate into patients. This is mainly due to interspecies variation in vascular regeneration, as well as inter-patient variation in factors influencing regeneration, such as gender, age, clinical condition, and use of medication. Following a review of vascular structure as a blueprint for tissue-engineered grafts and vascular pathologies necessitating such grafts, we describe potential mechanisms of host-graft interaction that explain outcome variability. Next, we propose research strategies to carefully move from understanding (variability in) vascular regeneration to robust and personalized graft design and outcomes.

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Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
F. J. Schoen
Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland
E. S. Fioretta & A. Mallone
Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands
A. I. P. M. Smits, L. Klouda & C. V. C. Bouten

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F. J. Schoen
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E. S. Fioretta
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A. Mallone
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A. I. P. M. Smits
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L. Klouda
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C. V. C. Bouten
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Correspondence to C. V. C. Bouten .

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Dept. of Cardiovascular Surgery, University Hospital Dept. of Cardiovascular Surgery, Geneva 14, Switzerland
Beat Walpoth
Center for Biomedical Research, Medical University Vienna Center for Biomedical Research, Vienna, Wien, Austria
Helga Bergmeister
Dept of Biomedical Engineering, University of Memphis Dept of Biomedical Engineering, Memphis, TN, USA
Gary Bowlin
Nankai University, Tianjin, China
Deling Kong
Zuid-Holland, Leiden University Medical Center Zuid-Holland, Leiden, The Netherlands
Joris Rotmans
University of Cape Town, Cape Town, Saudi Arabia
Peter Zilla

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Schoen, F.J., Fioretta, E.S., Mallone, A., Smits, A.I.P.M., Klouda, L., Bouten, C.V.C. (2020). Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications. In: Walpoth, B., Bergmeister, H., Bowlin, G., Kong, D., Rotmans, J., Zilla, P. (eds) Tissue-Engineered Vascular Grafts. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-71530-8_15-1

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DOI: https://doi.org/10.1007/978-3-319-71530-8_15-1
Received: 20 June 2019
Accepted: 27 September 2019
Published: 26 October 2019
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-71530-8
Online ISBN: 978-3-319-71530-8
eBook Packages: Springer Reference EngineeringReference Module Computer Science and Engineering

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