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Tissue-Engineered Vascular Grafts

  • Living reference work
  • © 2020

Overview

Editors:
  1. Beat Walpoth

    1. Dept. of Cardiovascular Surgery, University Hospital Dept. of Cardiovascular Surgery, Geneva 14, Switzerland

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  2. Helga Bergmeister

    1. Center for Biomedical Research, Medical University Vienna Center for Biomedical Research, Vienna, Austria

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  3. Gary Bowlin

    1. Dept of Biomedical Engineering, University of Memphis Dept of Biomedical Engineering, Memphis, USA

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  4. Deling Kong

    1. Nankai University, Tianjin, China

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  5. Joris Rotmans

    1. Zuid-Holland, Leiden University Medical Center Zuid-Holland, Leiden, The Netherlands

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  6. Peter Zilla

    1. University of Cape Town, Cape Town, Saudi Arabia

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  • Covers all approaches for vascular tissue engineering
  • Provides frequent updates in the fast growing field of regenerative medicine
  • Authors are key opinion leaders in their field

Part of the book series: Reference Series in Biomedical Engineering (RSBE)

Part of the book sub series: Tissue Engineering and Regeneration (TIENRE)

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Table of contents (19 entries)

  1. Advances in Cell Seeding of Tissue Engineered Vascular Grafts

    • Justin S. Weinbaum, Darren G. Haskett, Talya F. Mandelkern, David A. Vorp

  2. Autologous Mandril-Based Vascular Grafts

    • Wouter J. Geelhoed, Lorenzo Moroni, Joris I. Rotmans

  3. Bioengineered Human Acellular Vessels

    • Juan Wang, Jonathan Wu, Jeffrey H. Lawson, Laura E. Niklason

  4. Clinical Applications and Limitations of Vascular Grafts

    • Timothy Pennel, Peter Zilla

  5. Decellularized Vascular Grafts

    • Sotiria Toumpaniari, Andres Hilfiker, Axel Haverich, Sotirios Korossis

  6. Elastin in Vascular Grafts

    • Richard Wang, Bente J. de Kort, Anthal I. P. M. Smits, Anthony S. Weiss

  7. In Vivo Tissue-Engineered Vascular Grafts

    • Beat H. Walpoth, Sarra de Valence, Jean-Christophe Tille, Damiano Mugnai, Tornike Sologashvili, Wojciech MrówczyÅ„ski et al.

  8. Mechanical Testing of Vascular Grafts

    • Martin Stoiber, Christian Grasl, Francesco Moscato, Heinrich Schima

  9. Off-the-Shelf Tissue-Engineered Vascular Conduits: Clinical Translation

    • Emanuela S. Fioretta, Lisa von Boehmer, Melanie Generali, Simon P. Hoerstrup, Maximilian Y. Emmert

  10. Preclinical In-Vivo Assessment of Tissue Engineered Vascular Grafts and Selection of Appropriate Animal Models

    • Helga Bergmeister, Bruno K. Podesser

  11. Small-Diameter Engineered Arteries: The Gel Approach

    • Brett C. Isenberg, Chrysanthi Williams, Zeeshan H. Syedain, Robert T. Tranquillo

  12. Synthetic Materials: Processing and Surface Modifications for Vascular Tissue Engineering

    • William E. King III, Benjamin A. Minden-Birkenmaier, Gary L. Bowlin

  13. Textile-Reinforced Scaffolds for Vascular Tissue Engineering

    • Alicia Fernández-Colino, Stefan Jockenhoevel

  14. The Incorporation and Release of Bioactive Molecules in Vascular Grafts

    • Muhammad Shafiq, Hongyu Yan, Adam C. Midgley, Kai Wang, Qiang Zhao, Deling Kong

  15. Tissue Engineering to Study and Treat Cardiovascular Calcification

    • Mark C. Blaser, Samantha K. Atkins, Elena Aikawa

  16. Tissue-Engineered Vascular Grafts for Children

    • Toshihiro Shoji, Christopher Breuer, Toshiharu Shinoka

  17. Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications

    • F. J. Schoen, E. S. Fioretta, A. Mallone, A. I. P. M. Smits, L. Klouda, C. V. C. Bouten

  18. Vascular Tissue Engineering: The Role of 3D Bioprinting

    • Yu Shrike Zhang, Ali Khademhosseini

  19. Vascularization of 3D Engineered Tissues

    • Young Min Ju, Anthony Atala, James J. Yoo
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Keywords

About this book

Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. 
Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery.
 
Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE.  All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications.
 
The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment.
 
Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.

Editors and Affiliations

  • Dept. of Cardiovascular Surgery, University Hospital Dept. of Cardiovascular Surgery, Geneva 14, Switzerland

    Beat Walpoth

  • Center for Biomedical Research, Medical University Vienna Center for Biomedical Research, Vienna, Austria

    Helga Bergmeister

  • Dept of Biomedical Engineering, University of Memphis Dept of Biomedical Engineering, Memphis, USA

    Gary Bowlin

  • Nankai University, Tianjin, China

    Deling Kong

  • Zuid-Holland, Leiden University Medical Center Zuid-Holland, Leiden, The Netherlands

    Joris Rotmans

  • University of Cape Town, Cape Town, Saudi Arabia

    Peter Zilla

About the editors

Beat H. Walpoth, MD, PD, FAHA, is a trained cardiovascular surgeon, past Director of Cardiovascular Research in the Department of Surgery at Geneva University Hospital, Switzerland. He obtained his medical degree in 1972 at Zurich University, followed by Board of Surgery (including thoracic and cardiovascular) in 1982.  Postgraduate training included two years at the Peter Bent Brigham, a Harvard university hospital, Boston (1973-75) and cardiac transplantation at Stanford University (1982-84). Teaching appointments were held at Harvard Medical School, Universities of Bern and Geneva (Emeritus) and still ongoing in Verona University (Visiting Professor).  Dr. Walpoth is a recipient of several national and international awards, including the European Society for Artificial Organs (ESAO) Wichtig Award in the years 2008 and 2012 for his group’s research on Vascular Tissue Engineering.  He has over 150 publications, of which more than 50 are first-author papers, in peer reviewedjournals. Past-president of the ESAO; organizer of the Annual Congresses of the ESAO in 2000 in Lausanne, and 2008 in Geneva. He has also been responsible for the bi-annual Swiss Experimental Surgery Symposium (2006, 2008, 2010, 2012 and 2016).  As from 2004 he is a member of the International Faculty for Artificial Organs and the Director of the Internationally Co-tutored PhD Course in Biotechnology and Bioengineering (Universities of Geneva and Verona) since 2005.  Currently, he holds the presidency of the International Symposium on Vascular Tissue Engineering (ISVTE) and has created the TERMIS Thematic Group on Vascular Tissue Engineering.  His current main areas of interest include vascular tissue engineering and bio-artificial cardiovascular support.

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