Overview
- Editors:
-
-
Charles H. Streuli
-
The Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester, UK
-
Michael E. Grant
-
The Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester, UK
Access this book
Other ways to access
Table of contents (29 protocols)
-
Cell Biology of the Extracellular Matrix
-
Front Matter
Pages 209-209
-
- Christopher S. Chen, Emanuele Ostuni, George M. Whitesides, Donald E. Ingber
Pages 209-219
-
- Bo Zheng, David R. Clemmons
Pages 221-230
-
-
- Daniel E. Emerling, Arthur D. Lander
Pages 245-256
-
- José MarÍa Frade, Alfredo Rodriguez Tébar
Pages 257-264
-
- Emma E. Frost, Richard Milner, Charles ffrench-Constant
Pages 265-278
-
-
-
-
- Ronda E. Schreiber, Anthony Ratcliffe
Pages 301-309
-
- Patricia Simon-Assmann, Michèle Kedinger
Pages 311-319
-
- Paola Spessotto, Emiliana Giacomello, Roberto Perris
Pages 321-343
-
- Teresa C. M. Klinowska, Charles H. Streuli
Pages 345-358
-
Back Matter
Pages 359-370
About this book
It is now widely accepted that much of the dynamic function of cells and tissues is regulated from outside the cell by the extracellular matrix. In ad- tion to its conventional role in providing a scaffold for building tissues, the extracellular matrix acts as a directional highway for cellular movement and provides instructional information for promoting survival, proliferation, and differentiation. Indeed, the extracellular matrix is beginning to take a starring role in the choreography of cell and tissue function. The diverse roles of the extracellular matrix are reflected in its highly complicated structure, consisting of an ever increasing number of components. Yet the mechanisms of extracellular matrix assembly and how they influences cell behavior are only just beginning to be understood. In order to solve these problems new methodologies are, of necessity, being developed. Many of these technologies are highly sophisticated and are currently available only in a ha- ful of laboratories. However, we believe that they can readily be transported and established by other researchers. Thus, the purpose of Extracellular Matrix Protocols is to present some of these complicated techniques in a style that is relatively easy to reproduce.
Reviews
"This would be most useful to a lab researcher who had not previously been studying the role of the ECM in biological systems, and who wished to do so. Having all the practical protocols for preparing, assaying, and studying these important molecules in a small volume could be very useful for such a researcher."-Doody's Health Science Book Review Journal