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N-Oxidation of Drugs

Biochemistry, pharmacology, toxicology

  • Book
  • © 1991

Overview

Editors:
  1. P. Hlavica

    1. Ludwig-Maximilians-Universität München, Munich, Germany

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  2. L. A. Damani

    1. Chelsea Department of Pharmacy, King’s College, University of London, UK

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xx
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  2. Analysis of N-Oxidized Products

    1. Front Matter

      Pages 1-1
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    2. Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products

      • T. E. Eling, J. F. Curtis, D. C. Thompson, J. Van der Zee, R. P. Mason
      Pages 3-18

    3. The Application of 15N-NMR in the Analysis of N-Oxygenated amidines and guanidines

      • B. Clement, Th. Kämpchen
      Pages 19-35

    4. Radioimmunoassay and other methods for trace analysis of N-oxide compounds

      • K. K. Midha, T. J. Jaworski, E. M. Hawes, G. McKay, J. W. Hubbard, M. Aravagiri et al.
      Pages 37-55

  3. Enzymology of N-Oxidation

    1. Front Matter

      Pages 57-57
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    2. Mechanism, multiple forms and substrate specificities of flavin-containing mono-oxygenases

      • D. M. Ziegler
      Pages 59-70

    3. On the genetic polymorphism of the flavin-containing mono-oxygenase

      • P. Hlavica, I. Golly
      Pages 71-90

    4. Factors regulating the activity of the rabbit lung flavin-containing mono-oxygenase

      • D. E. Williams
      Pages 91-105

    5. Human pharmacogenetics of nitrogen oxidations

      • S. Cholerton, R. L. Smith
      Pages 107-131

    6. Microbial N-hydroxylases

      • H. Diekmann, H. J. Plattner
      Pages 133-139

    7. Roles of aminium radical intermediates in the biotransformation of dihydropyridines, cycloalkylamines, and N,N-dimethylanilines by cytochrome P-450 enzymes

      • F. P. Guengerich, A. Bondon, R. G. Böcker, T. L. Macdonald
      Pages 141-155

    8. The role of cytochrome P-450 in the biological nuclear N-oxidation of aminoaza-heterocyclic drugs and related compounds

      • J. W. Gorrod, S. P. Lam
      Pages 157-184

    9. New aspects of the microsomal N-hydroxylation of benzamidines

      • B. Clement, M. Immel, H. Pfundner, S. Schmitt, M. Zimmermann
      Pages 185-205

    10. Studies on the N-oxidation of phentermine: evidence for an indirect pathway of N-oxidation mediated by cytochrome P-450

      • A. K. Cho, J. D. Duncan, J. M. Fukuto
      Pages 207-215

    11. Molecular activation mechanisms involved in arylamine cytotoxicity: peroxidase products

      • P. J. O’Brien, S. Jatoe, L. G. McGirr, S. Khan
      Pages 217-236

  4. Reductions and Conjugations of N-Oxygenated Compounds

    1. Front Matter

      Pages 237-237
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    2. Reduction and conjugation reactions of N-oxides

      • L. A. Damani
      Pages 239-261

    3. In vivo metabolism of N-oxides

      • E. M. Hawes, T. J. Jaworski, K. K. Midha, G. McKay, J. W. Hubbard, E. D. Korchinski
      Pages 263-286

    4. Purification and characterization of rat hepatic acetyltransferase

      • C. M. King, S. J. Land
      Pages 287-292
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Keywords

Editors and Affiliations

  • Ludwig-Maximilians-Universität München, Munich, Germany

    P. Hlavica

  • Chelsea Department of Pharmacy, King’s College, University of London, UK

    L. A. Damani

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