Abstract
Amidines are formally derived from carboxylic acids by substitution of the two oxygen atoms for nitrogen atoms. Thus, they possess the same oxidation level as carboxylic acids and their derivatives. Under no circumstances should amidines be confused with imines which are derivatives of ketones and aldehydes or with guanidines which are derived from carbonic acid. This is wrong not only for purely formal reasons but also because of differing chemical properties and differing behaviour in biotransformation reactions. Analogously, the N-oxygenated derivatives — oximes, amidoximes, N—hydroxyguanidines, respectively — formed by N-hydroxylation have very little in common (Clement, 1989a).
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Clement, B., Immel, M., Pfundner, H., Schmitt, S., Zimmermann, M. (1991). New aspects of the microsomal N-hydroxylation of benzamidines. In: Hlavica, P., Damani, L.A. (eds) N-Oxidation of Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3112-4_11
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DOI: https://doi.org/10.1007/978-94-011-3112-4_11
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