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Studies on the N-oxidation of phentermine: evidence for an indirect pathway of N-oxidation mediated by cytochrome P-450

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N-Oxidation of Drugs

Abstract

This chapter summarizes results of our investigations on the oxidation of aliphatic nitrogen functions. For some time we have been studying the metabolism of arylalkylamines related to amphetamine. Our focus has been on amphetamine and phentermine and their N-hydroxy derivatives.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Jonsson Comprehensive Cancer, UCLA Center for Health Sciences, Los Angeles, CA, USA

    A. K. Cho, J. D. Duncan & J. M. Fukuto

Authors
  1. A. K. Cho
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  2. J. D. Duncan
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  3. J. M. Fukuto
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Editor information

Editors and Affiliations

  1. Ludwig-Maximilians-Universität München, Munich, Germany

    P. Hlavica (Full Professor of Pharmacology and Toxicology) (Full Professor of Pharmacology and Toxicology)

  2. Chelsea Department of Pharmacy, King’s College, University of London, UK

    L. A. Damani (Lecturer in Biopharmacy) (Lecturer in Biopharmacy)

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© 1991 Springer Science+Business Media Dordrecht

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Cho, A.K., Duncan, J.D., Fukuto, J.M. (1991). Studies on the N-oxidation of phentermine: evidence for an indirect pathway of N-oxidation mediated by cytochrome P-450. In: Hlavica, P., Damani, L.A. (eds) N-Oxidation of Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3112-4_12

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  • DOI: https://doi.org/10.1007/978-94-011-3112-4_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5378-5

  • Online ISBN: 978-94-011-3112-4

  • eBook Packages: Springer Book Archive

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