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Accuracy in Molecular Processes

Its Control and Relevance to Living System

  • T. B. L. Kirkwood
  • R. F. Rosenberger
  • D. J. Galas

Table of contents

  1. Front Matter
    Pages i-xiv
  2. D. J. Galas, T. B. L. Kirkwood, R. F. Rosenberger
    Pages 1-16
  3. R. F. Rosenberger, T. B. L. Kirkwood
    Pages 17-35
  4. A. R. Fersht
    Pages 67-82
  5. R. H. Buckingham, H. Grosjean
    Pages 83-126
  6. C. G. Kurland, J. A. Gallant
    Pages 127-157
  7. R. P. Anderson, J. R. Menninger
    Pages 159-189
  8. M. F. Goodman, E. W. Branscomb
    Pages 191-232
  9. S. G. Sedgwick
    Pages 233-289
  10. M. Ehrenberg, C. G. Kurland, C. Blomberg
    Pages 329-361
  11. T. B. L. Kirkwood, R. Holliday
    Pages 363-379
  12. Back Matter
    Pages 393-398

About this book

Introduction

Molecular biology proceeds at unremitting pace to unfold new secrets of the living world. Biology, long regarded as an inexact companion to physics and chemistry, has undergone transformation. Now, chemical and physical principles are tools in understanding highly complex biomolecular processes, whose origin lies in a history of chance, constraint and natural selection. The accuracy of these processes, often remarkably high, is crucial to their self­ perpetuation, both individually and collectively, as ingredients of the organism as a whole. In this book are presented thirteen chapters which deal with various facets of the accuracy problem. Subjects covered include: the specificity of enzymes; the fidelity of synthesis of proteins; the replication and repair of DNA: general schemes for the enhancement of biological accuracy; selection for an optimal balance between the costs and benefits of accuracy; and the possible relevance of molecular mistakes to the process of ageing. The viewpoints are distinct, yet complementary, and the book as a whole offers to researchers and students the first comprehensive account of this growing field.

Keywords

DNA DNA repair RNA Termination biology chemistry enzymes evolution molecular biology molecular evolution molecular mechanisms protein tRNA transcription translation

Editors and affiliations

  • T. B. L. Kirkwood
    • 1
  • R. F. Rosenberger
    • 1
  • D. J. Galas
    • 2
  1. 1.National Institute for Medical ResearchLondonUK
  2. 2.University of Southern CaliforniaLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-4097-0
  • Copyright Information Springer Science+Business Media B.V. 1986
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-8318-8
  • Online ISBN 978-94-009-4097-0
  • Buy this book on publisher's site