Handbook of Downstream Processing

  • Elliott Goldberg

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. J. R. Millis
    Pages 1-19
  3. R. Wolthuis, V. C. Dichiaria
    Pages 20-47
  4. D. J. Odde
    Pages 70-89
  5. T. A. Davis, D. A. Glassner
    Pages 140-166
  6. J. W. Snowman
    Pages 203-234
  7. A. S. Mujumdar, D. S. Alterman
    Pages 235-260
  8. P. M. Armenante, A. C. Kirpekar
    Pages 261-308
  9. W. C. Czander, R. V. Leung
    Pages 309-317
  10. J. A. Covey, J. Brown
    Pages 318-334
  11. R. J. McDonough
    Pages 357-416
  12. R. F. Wilcox
    Pages 417-455
  13. S. Fishkin
    Pages 456-508
  14. S. Litman
    Pages 509-529
  15. S. Norwood
    Pages 530-556

About this book


The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized­ in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?


Downstream Processing Fermenter Lysin biochemical engineering biotechnology chromatography filtration microorganism protein wastewater

Editors and affiliations

  • Elliott Goldberg
    • 1
  1. 1.Lockwood Greene Engineers, Inc.New YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-1563-3
  • Copyright Information Springer Science+Business Media B.V. 1997
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7198-7
  • Online ISBN 978-94-009-1563-3
  • About this book
Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods