Abstract
The disruption of microorganisms is often required in the large-scale production of microbial products, such as enzymes, toxins, and diagnostic or therapeutic proteins. Many alternatives for release of product from cells exist for the process engineer: for example, mechanical disruption, autolysis, and chemical or enzymatic lysis. Genetic advances have also led to microbial host-vector systems, which secrete products from the cell, thus lowering contamination and lessening the risk of proteolysis. However, for many products of interest, these systems are either not available or not applicable.
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Millis, J.R. (1997). Mechanical disruption of cells. In: Goldberg, E. (eds) Handbook of Downstream Processing. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1563-3_1
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DOI: https://doi.org/10.1007/978-94-009-1563-3_1
Publisher Name: Springer, Dordrecht
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