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The Chemistry of Antitumour Agents

  • Derry E. V. Wilman

Table of contents

  1. Front Matter
    Pages i-xiii
  2. W. A. Denny
    Pages 1-29
  3. A. Suarato
    Pages 30-62
  4. I. Niculescu-Duvǎz, I. Baracu, A. T. Balaban
    Pages 63-130
  5. J. A. Montgomery, T. P. Johnston
    Pages 131-158
  6. K. Vaughan
    Pages 159-186
  7. M. D. Threadgill
    Pages 187-201
  8. M. G. Nair
    Pages 202-233
  9. M. MacCoss, M. J. Robins
    Pages 261-298
  10. R. K. Robins, G. D. Kini
    Pages 299-321
  11. D. E. V. Wilman
    Pages 322-330
  12. M. J. Abrams
    Pages 331-341
  13. K. S. P. Bhushana Rao, M.-P. Collard, J. P. Dejonghe, A. Trouet
    Pages 370-378
  14. R. W. Franck, M. Tomasz
    Pages 379-394
  15. S. M. Hecht
    Pages 395-402
  16. A. B. Mauger
    Pages 403-409
  17. M. Sainsbury
    Pages 410-435
  18. Back Matter
    Pages 436-441

About this book

Introduction

Walter C. J. ROSS Emeritus Professor, University of London To paraphrase a statement made by Howard E. Skipper many years ago, 'We cancer chemotherapists have often exploited and overworked our chemist colleagues and they have been conveniently forgotten at award giving times'. This book is an attempt to rectify this and highlight the contribution of the chemist in modifying the structure of various types of agent to enhance their effectiveness as inhibitors of the growth of neoplastic tissues. Cancer chemotherapy is a relatively new discipline, coming later than the introduction of sulphonamides and antibiotics. Modern anti-cancer therapy started with the report of the use of a war gas methyl-di-(2-chloroethyl)amine (HN2) in 1946 for the treatment of Hodgkin's disease. The recognition that this compound acted as a bifunctional alkylating agent under physiological conditions led to the synthesis of a wide range of drugs with similar properties. Amongst these were chlorambucil, melphalan, busulphan, and cyclophos­ phamide which still find use today. Somewhat later, a range of antibiotics was found to be effective, for example aminopterin (1948) and 6-mercaptopurine (1958) to treat acute leukaemias and 5-fluorouracil and 6-azauracil (1957-8) which were used against a variety of cancers. Since these early days the net has been cast ever wider and, as well as ingenious modifications of the compounds mentioned above, anticancer drugs now include growing classes of compounds ranging from purely synthetic agents to natural products. Many of these are discussed in the present book.

Keywords

DNA Rearrangement classification hormones steroids tumor

Editors and affiliations

  • Derry E. V. Wilman
    • 1
  1. 1.Drug Development SectionInstitute of Cancer ResearchUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-0397-5
  • Copyright Information Springer Science+Business Media B.V. 1990
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6665-5
  • Online ISBN 978-94-009-0397-5
  • Buy this book on publisher's site
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