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Antitumour anthracyclines

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The Chemistry of Antitumour Agents

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Abstract

The first reports on structure and chemotherapeutic potential of two ‘red pigments’ belonging to the anthracycline class of natural products, daunorubicin and doxorubicin, were published 20 years ago. Since then many other anthracyclines have been studied, but it was only the discovery of the potent antineoplastic activity of doxorubicin and its subsequent fast approval in 1974 by the U.S. Federal Drug Administration (FDA) as a prescription drug which triggered off the attention of the scientific community. The search for other anthracycline analogues with better therapeutic indices than doxorubicin has been tenaciously pursued in many laboratories around the world. The therapeutic efficacy of doxorubicin was limited by toxic side effects, mainly cardiotoxicity and myelosuppression. The research efforts have brought the discovery of other clinically useful anthracyclines, such as aclacinomycin A and carminomycin, isolated from natural sources, and the discovery, in synthetic laboratories, that minor structural changes in the lead compound doxorubicin might significantly improve the therapeutic index.

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  1. Drug Development Section, Institute of Cancer Research, UK

    Derry E. V. Wilman

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Suarato, A. (1990). Antitumour anthracyclines. In: Wilman, D.E.V. (eds) The Chemistry of Antitumour Agents. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0397-5_2

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