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Chemistry of antifolates

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The Chemistry of Antitumour Agents

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Abstract

Cancer can be defined as a disease that is characterised by a failure of the control mechanisms that are involved in cell division. Rapidly proliferating cells have a higher demand for DNA, and consequently require large quantities of purine and pyrimidine nucleotide substrates. Folic acid (1) plays a central role in the de novo biosynthesis of DNA. The coenzyme N5,N10-methylenetetrahydrofolate provides the one carbon unit necessary for the conversion of deoxyuridine monophosphate (dUMP) to thymidylic acid (dTMP).

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  1. Drug Development Section, Institute of Cancer Research, UK

    Derry E. V. Wilman

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Nair, M.G. (1990). Chemistry of antifolates. In: Wilman, D.E.V. (eds) The Chemistry of Antitumour Agents. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0397-5_7

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