© 2012

Tumors of the Central Nervous System, Volume 5

Astrocytomas, Hemangioblastomas, and Gangliogliomas

  • M.A. Hayat

Part of the Tumors of the Central Nervous System book series (TCNS, volume 5)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Astrocytomas: Diagnosis and Biomarkers

    1. Front Matter
      Pages 1-1
    2. María del Mar Inda, Juan A. Rey, Xing Fan, Javier S. Castresana
      Pages 3-12
    3. Alberto Azzalin, Sergio Comincini
      Pages 13-22
    4. Alfredo Conti, Carlo Gulì, Giuseppe J. Sciarrone, Chiara Tomasello
      Pages 23-33
    5. Gangadhara Reddy Sareddy, Phanithi Prakash Babu
      Pages 35-44
    6. Katarzyna Kotulska, Sergiusz Jóźwiak
      Pages 45-55
    7. Ignacio Camacho-Arroyo, Valeria Hansberg-Pastor, Edith Cabrera-Muñoz, Olivia Tania Hernández-Hernández, Aliesha González-Arenas
      Pages 57-63
    8. Joonas Haapasalo, Hannu Haapasalo, Seppo Parkkila
      Pages 65-71
    9. Jai-Nien Tung, Tang-Yi Tsao, Kun-Tu Yeh, Ching-Fong Liao, Ming-Chung Jiang
      Pages 73-79
    10. Quincy Quick, Yihang Pan, Omar Skalli
      Pages 81-88
    11. Daniel L. Keene, Donna Johnston
      Pages 95-98
    12. Sally R. Lambert, David T. W. Jones
      Pages 99-105
    13. Anne F. Buckley, Roger E. McLendon, Carol J. Wikstrand, Darell D. Bigner
      Pages 107-119
    14. Timo Gaiser, Markus D. Siegelin
      Pages 135-142
    15. Mansoor Foroughi, Shibu Pillai, Paul Steinbok
      Pages 143-148
    16. Magdalena Ewa Tyburczy, Bozena Kaminska
      Pages 149-157

About this book


The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented.  The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.


Biomarkers for cancer Cancer diagnosis, intraoperative Cancer therapy Gene expression in cancer Imaging of cancer

Editors and affiliations

  • M.A. Hayat
    • 1
  1. 1., Kean UniversityRoom 213, Library buildingUnionUSA

Bibliographic information

  • Book Title Tumors of the Central Nervous System, Volume 5
  • Book Subtitle Astrocytomas, Hemangioblastomas, and Gangliogliomas
  • Editors M.A. Hayat
  • Series Title Tumors of the Central Nervous System
  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-94-007-2018-3
  • Softcover ISBN 978-94-007-3826-3
  • eBook ISBN 978-94-007-2019-0
  • Edition Number 1
  • Number of Pages XXVI, 290
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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From the reviews:

“This book covers the molecular, medical, radiosurgical, and surgical management of intracranial tumors including astrocytomas, hemangioblastomas, and gangliogliomas. The purpose is to address the most recent advances in the management of these tumors. Neurologists, neurosurgeons, and radiologists are the intended audience. … This is an excellent contribution to neurosurgery and should be part of most academic neurosurgery and neurology libraries.” (Celso Agner, Doody’s Review Service, April, 2012)