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  • © 2017

Renal Cell Carcinoma

Molecular Features and Treatment Updates

Editors:

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  • Provides a comprehensive review of diagnosis and treatments of renal cell carcinoma

  • Presents the most recent advances in molecular bases and targeted therapy for renal cell carcinoma

  • Contains important information about pharmacokinetics and pharmacodynamics in molecular- targeted agents of renal cell carcinoma

Buying options

eBook
USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-4-431-55531-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 199.99
Price excludes VAT (USA)
Hardcover Book
USD 199.99
Price excludes VAT (USA)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
  2. Epidemiology of Renal Cell Carcinoma

    • Xifeng Wu, Xiang Shu
    Pages 1-18
  3. Hereditary Renal Cell Carcinoma

    • Masaya Baba, Laura S. Schmidt, W. Marston Linehan
    Pages 19-82
  4. Molecular Genetics of Renal Cell Carcinoma

    • Tomoya Fukawa, Nicholas Shannon, Dachuan Huang, Jing Tan, Xiaosai Yao, Steven G. Rozen et al.
    Pages 83-103
  5. Pathology of Renal Cell Carcinoma

    • Shuji Mikami, Naoto Kuroda, Yoji Nagashima
    Pages 105-137
  6. Treatment Overview

    • Tsunenori Kondo
    Pages 177-207
  7. Natural History and Active Surveillance

    • Jaimin R. Bhatt, Patrick O. Richard, Michael A. S. Jewett
    Pages 209-220
  8. Surgical Treatment for Renal Cell Carcinoma

    • Dae Y. Kim, Jose A. Karam, Christopher G. Wood
    Pages 221-235
  9. Predictive and Prognostic Markers in Metastatic Renal Cell Carcinoma

    • JosĂ© Manuel Ruiz Morales, Daniel Y. C. Heng
    Pages 237-251
  10. Tyrosine Kinase Inhibitors: Sorafenib, Sunitinib, Axitinib, and Pazopanib

    • Christos E. Kyriakopoulos, Brian I. Rini
    Pages 253-272
  11. Mammalian Targets of Rapamycin Inhibitors: Temsirolimus and Everolimus

    • Camillo Porta, Silvia Chiellino, Mimma Rizzo
    Pages 273-294
  12. Immunotherapy for Renal Cell Cancer (RCC)

    • Shigehisa Kitano, Ayumu Ito, Youngji Kim
    Pages 295-317
  13. Refractory Mechanisms

    • Mototsugu Oya, Toshiaki Shinojima, Ryuichi Mizuno
    Pages 351-367

About this book

This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.

Keywords

  • Molecular-targeted therapy
  • TKI
  • anti-angiogenic agent
  • mTOR inhibitors
  • tyrosine-kinase inhibitors

Editors and Affiliations

  • Department of Urology, Keio University School of Medicine, Tokyo, Japan

    Mototsugu Oya

About the editor

Dr. Mototsugu Oya Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Bibliographic Information

  • Book Title: Renal Cell Carcinoma

  • Book Subtitle: Molecular Features and Treatment Updates

  • Editors: Mototsugu Oya

  • DOI: https://doi.org/10.1007/978-4-431-55531-5

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan KK 2017

  • License: CC BY

  • Hardcover ISBN: 978-4-431-55530-8

  • Softcover ISBN: 978-4-431-56661-8

  • eBook ISBN: 978-4-431-55531-5

  • Edition Number: 1

  • Number of Pages: X, 381

  • Number of Illustrations: 24 b/w illustrations, 54 illustrations in colour

  • Topics: Oncology, Urology, Biomedical Research

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buying options

eBook
USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-4-431-55531-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 199.99
Price excludes VAT (USA)
Hardcover Book
USD 199.99
Price excludes VAT (USA)