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Histamine and Histamine Antagonists

  • Book
  • © 1991

Overview

Editors:
  1. Börje Uvnäs

    1. Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 97)

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Table of contents (27 chapters)

  1. Histamine in Cardiovascular Function and Dysfunction: Recent Developments

    1. Histamine in Cardiovascular Function and Dysfunction: Recent Developments

      • R. Levi, L. E. Rubin, S. S. Gross
      Pages 347-383

  2. Histamine in Anaesthesia and Surgery: Causality Analysis

    1. Histamine in Anaesthesia and Surgery: Causality Analysis

      • W. Lorenz, W. Dietz, M. Ennis, B. Stinner, A. Doenicke
      Pages 385-439

  3. Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

    1. Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

      • J. Sattler, W. Lorenz, R. Lindlar, U. Schäfer
      Pages 441-472

  4. Histamine and the Blood

    1. Histamine and the Blood

      • K. Tasaka
      Pages 473-510

  5. Histamine in Food

    1. Histamine in Food

      • S. A. Slorach
      Pages 511-520

  6. Role of Histamine in the Actions of Neuropeptides and Local Hormones

    1. Role of Histamine in the Actions of Neuropeptides and Local Hormones

      • A. Chahl
      Pages 521-548

  7. Antagonists of H1 Receptors of Histamine: Recent Developments

    1. Antagonists of H1 Receptors of Histamine: Recent Developments

      • A. F. Casy
      Pages 549-572

  8. Structural Requirements for Histamine H2 Agonists and H2 Antagonists

    1. Structural Requirements for Histamine H2 Agonists and H2 Antagonists

      • H. van der Goot, A. Bast, H. Timmerman
      Pages 573-748

  9. Back Matter

    Pages 749-766
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Keywords

About this book

Together with the two previous volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines the present publication yields a picture of a still rapidly developing field of research. New techniques and new experimental approaches have brought us new knowledge and deeper insight into the biomedical significance of histamine, even if many questions remain to be answered about the functional and medical implications of this old biogenic amine. The present volume covers the progress in histamine research during the past two decades. A significant chapter concerns techniques for histamine determination. As the result of a consensus meeting in Munich in December 1988, a panel of eminent specialists arrived at common recommendations as to the usefulness of the available histamine assays for the most common experimental biomedical conditions. The heterogeneity of mast cells, with great differences in their reactivity to various stimuli, has become apparent, not only among species but also among the tissues of a species. New informa­ tion is presented about the mechanism of exocytosis. The old questions about the role of histamine in the mechanism of gastric secretion and in cardio­ vascular and respiratory functions have been studied with new techniques, and the role of HI and H2 receptors discussed. New observations have been made on the occurrence and possible functions of histaminergic neurons and histamine receptors in CNS where a new type of receptor, the H , seems to 3 be widely represented.

Editors and Affiliations

  • Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden

    Börje Uvnäs

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