Abstract
Soon after its discovery as a component of an ergot extract, histamine was found to exert marked effects on the cardiovascular system, hypotension and tachycardia being the most characteristic features (Dale and Laidlaw 1910). Although the baroreceptor reflex plays a role in the tachycardia elicited by histamine, this amine undoubtedly has direct cardiac effects. Receptor subtypes mediating cardiac responses to histamine have been characterized pharmacologically using selective H1 - and H2-receptor agonists and antagonists; binding studies, however, have provided little information due to a lack of suitable radioligands having sufficiently high affinity and specificity. The large body of literature on the actions of histamine on the mammalian heart has been reviewed in extenso in a previous volume of this series (Altura and Halevy 1978) and elsewhere (Levi et al. 1982; Wolff and Levi 1986). Thus, only the most recent developments on this subject will be considered here.
Keywords
- Histamine Release
- Histamine Receptor
- Positive Inotropic Effect
- Systemic Mastocytosis
- Atrioventricular Node
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Supported by United States National Institutes of Health, grant No. HL 34215.
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Levi, R., Rubin, L.E., Gross, S.S. (1991). Histamine in Cardiovascular Function and Dysfunction: Recent Developments. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_20
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