Abstract
In the early 1930s, many investigators attempted to measure the histamine levels in whole blood, and to study the distribution of histamine in the plasma and blood cells. In 1937, Code reported that the majority of histamine in human blood was detected in the leucocytes; later, it was found that about 50% of the histamine in whole blood exists in the basophils (Graham et al. 1955). Since then, researchers have come to believe that basophils are important storage sites of histamine in the blood. In 1953, Riley and West found that abundant histamine exists in mast cells and that these cells are the major source of histamine in the tissue. It became apparent that the histamine content in basophils was considerably less than that in mast cells. However, there are some analogies between basophils and mast cells, especially with regard to the release of histamine during anaphylactic reactions. Other important effects of histamine appear in the eosinophils and lymphocytes. It is known that the eosinophils are in some way related to mast cells in the tissue, particularly regarding immediate hypersensitivity. Histamine modulated a variety of lymphocyte functions which are considered to be important in regulating immune reactions.
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References
Adachi K, Aoyagi T, Iizuka H, Halprin KM, Levin, V (1980) Cyclic GMP system in the epidermis. Curr Probl Dermatol 10:39–65
Alam R, Rozniecki J, Kuzminska B (1985) A lymphocyte-derived histamine-releasing factor in asthmatic patients. III. Further studies. Ann Allergy 55:825–829
Alam R, Kuna P, Rozniecki J, Kuzminska B (1986) Bacterial antigens stimulate the production of histamine releasing factor (HRF) by lymphocytes from intrinsic asthmatic patients. Clin Exp Immunol 63:241–248
Almeida AP, Flye W, Deveraux D, Horakova Z, Beaven MA (1980) Distribution of histamine and histaminase (diamine oxidase) in blood of various species. Comp Biochem Physiol [C] 67:187–190
Anderson R, Glover A, Rabson AR (1977) The in vitro effects of histamine and metiamide on neutrophil motility and their relationship to intracellular cyclic nucleotide levels. J Immunol 118:1690–1696
Anton AH, Sayre DF (1969) A modified fluorometric procedure for tissue histamine and its distribution in various animals. J Pharmacol Exp Ther 166:285–292
Anwar ARE, Kay AB (1978) Enhancement of human eosinophil complement receptors by pharmacologic mediators. J Immunol 121:1245–1250
Anwar ARE, Kay AB (1980) H1-receptor dependence of histamine-induced enhancement of human eosinophil C3b rosettes. Clin Exp Immunol 42:196–199
Bainton DF, Farquhar MG (1970) Segregation and packaging of granule enzymes in eosinophilic leukocytes. J Cell Biol 45:54–73
Ballet JJ, Merler E (1976) The separation and reactivity in vitro of a subpopulation of human lymphocytes which binds to histamine. Correlation of histamine reactivity with cellular maturation. Cell Immunol 24:250–269
Bardsley WG, Crabbe MJC, Scott IV (1974) The amine oxidases of human placenta and pregnancy plasma. Biochem J 139:169–181
Barsoum GS, Gaddum JH (1935) The pharmacological estimation of adenosine and histamine in blood. J Physiol (Lond) 85:1–14
Baylin SB, Margolis S (1975) Purification of histaminase (diamine oxidase) from human pregnancy plasma by affinity chromatography. Biochim Biophys Acta 397:294–306
Baylin SB, Beaven MA, Buja LM, Keiser HR (1972) Histaminase activity: a biochemical marker for medullary carcinoma of the thyroid. Am J Med 53:723–733
Baylin SB, Abeloff MD, Wieman RC, Tomford JW, Ettinger DS (1975) Elevated histaminase (diamine oxidase) activity in small cell carcinoma of the lung. N Engl J Med 293:1286–1290
Beaven MA (1982) Factors regulating availability of histamine at tissue receptors. In: Ganellin CR, Parsons ME (eds) Pharmacology of histamine receptors. Wright, London, pp 103–145
Beaven MA, Horakova Z (1978) The enzymatic isotopic assay of histamine. In: Rocha e Silva M (ed) Histamine and anti-histaminics., part II. Springer, Berlin Heidelberg New York, pp 151–173 (Handbuch der experimentellen Pharmakologie, vol 18/2)
Beaven MA, Jacobsen S, Horáková Z (1972) Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine. Clin Chim Acta 37:91–103
Beaven MA, Marshall JR, Baylin SB, Sjoerdsma A (1975) Changes in plasma activity during normal early human pregnancy and pregnancy disorders. Am J Obstet Gynecol 123:605–609
Beaven MA, Moore JP, Smith GA, Hesketh TR, Metcalfe JC (1984) The calcium signal and phosphatidylinostiol breakdown in 2H3 cells. J Biol Chem 259: 7137–7142
Belcher NG, Murdoch R, Dalton N, Clark TJH, Rees PJ, Lee TH (1988) Circulating concentrations of histamine, neutrophil chemotactic activity, and catecholamines during the refractory period in exercise-induced asthma. J Allergy Clin Immunol 81:100–110
Bhat KN, Arroyave CM, Marney SR Jr, Stevenson DD, Tan EM (1976) Plasma histamine changes during provoked bronchospasm in asthmatic patients. J Allergy Clin Immunol 58:647–656
Bjurö T, Lindberg S, Westling H (1961) Observations on histamine in pregnancy and the puerperium. Acta Obst Gynecol Scand 40:152–173
Burgess AW, Metcalf D (1980) The nature and action of granulocyte-macrophage colony stimulating factors. Blood 56:947–958
Burgoyne RD (1987) Control of exocytosis. Nature 328:112–113
Burtin C (1986) Mast cells and tumour growth. Ann Inst Pasteur Immunol 137D: 289–294
Burtin C, Scheinmann P, Salomon JC, Lespinats G, Frayssinet C, Lebel B, Canu P (1981) Increased tissue histamine in tumour-bearing mice and rats. Br J Cancer 43:684–688
Busse WW (1977) Decreased granulocyte response to isoproterenol in asthma during upper respiratory infections. Am Rev Respir Dis 115:783–791
Busse WW, Sosman J (1976) Histamine inhibition of neutrophil lysosomal enzyme release: an H2 receptor response. Science 194:737–738
Busse WW, Sosman J (1977) Decreased H2 histamine response of granulocytes of asthmatic patients. J Clin Invest 59:1080–1087
Byron JW (1976) Bone-marrow toxicity of metiamide. Lancet 2:1350
Byron JW (1980) Pharmacodynamic basis for the interaction of cimetidine with the bone marrow stem cells (CFU-S). Exp Hematol 8:256–263
Carlsson R, Dohlsten M, Sjögren HO (1985) Histamine modulates the production of interferon-γ and interleukin-2 by mitogen-activated human mononuclear blood cell. Cell Immunol 96:104–112
Charles TJ, Williams SJ, Seaton A, Bruce C, Taylor WH (1979) Histamine, basophils and eosinophils in severe asthma. Clin Sci 57:39–45
Church MK, Pao GJ-K, Holgate ST (1982) Characterization of histamine secretion from mechanically dispersed human lung mast cells: effects of anti-IgE, calcium ionophore A23187, compound 48/80, and basic polypeptides. J Immunol 129: 2116–2121
Church MK, Holgate ST, Hughes PJ (1983) Adenosine inhibits and potentiates IgE-dependent histamine release from human basophils by an A2-receptor mediated mechanism. Br J Pharmacol 80:719–726
Clark RAF, Gallin, JI, Kaplan A (1975) The selective eosinophil chemotactic activity of histamine. J Exp Med 142:1462–1476
Clark RAF, Sandler JA, Gallin JI, Kaplan AP (1977) Histamine modulation of eosinophil migration. J Immunol 118:137–145
Coble BI, Lindroth M, Molin L, Stendahl O (1984) Histamine release from mast cells during phagocytosis and interaction with activated neutrophils. Int Arch Allergy Appl Immunol 75:32–37
Code CF (1937) The quantitative estimation of histamine in the blood. J Physiol 89:257–268
Code CF (1952) Histamine in blood. Physiol Rev 32:47–65
Code CF (1976) Suppression of histamine leucocytosis by metiamide. J Physiol (Lond) 254:31P-32P
Cotran RS, Litt M (1969) The entry of granule-associated peroxidase into the phagocytic vacuole of eosinophils. J Exp Med 129:1291–1306
Crews FT, Morita Y, McGivney A, Hirata F, Siraganian RP, Axelrod J (1981) IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid. Archs Biochem Biophys 212:561–571
De Boer M, Roos D (1986) Metabolic comparison between basophils and other leukocytes from human blood. J Immunol 136:3447–3454
De Galocsy C, van Ypersele de Strihou C (1979) Pancytopenia with cimetidine. Ann Intern Med 90:274
De Gara PF (1951) Chemical determination of histamine in blood in health and disease. J Allergy 22:429–433
Diaz P, Jones DG, Kay AB (1979) Histamine receptors on guinea-pig alveolar macrophages: chemical specificity and the effect of H1- and H2-receptor agonist and antagonist. Clin Exp Immunol 35:462–469
Dohlsten M, Sjögren HO, Carlsson R (1986) Histamine inhibits interferon-γ production via suppression of interleukin 2 synthesis. Cell Immunol 101:493–501
Dubois A-M, Santais M-C, Foussard C, Dubois F, Ruff F, Taurelle R, Parrot J-L (1977) Blood histamine and plasma histaminase level during human pregnancy. Agents Actions 7:112
Dunér H, Pernow H, Sterky G (1960) The histamine concentration of the blood on exposure to cold and heat. A study in healthy subjects and patients with cold allergy. Acta Allergol (Copenh) 15:417–424
Eckert R, Repke H (1986) Histamine as endogenous immunomodulator. Methods Find Exp Clin Pharmacol 8:183–187
Effkemann G, Werle E (1940) Die Bedeutung des Histaminstoffwechsels im weiblichen schwangeren und nichtschwangeren Organismus. Arch Gynakol 170: 173–192
Enerbäch L, Lindenger G, Loo TV, Granerus G (1985) Cellular repository for blood histamine in normal and nematode-infected rats. Agents Actions 16:87–90
Fantozzi R, Brunelleschi S, Giuliattini L, Blandina P, Masini E, Cavallo G, Mannaioni PF (1985) Mast cell and neutrophil interactions: a role for superoxide anion and histamine. Agents Actions 16:260–264
Fantozzi R, Brunelleschi S, Rubino A, Tarli S, Masini E, Mannaioni PF (1986) FMLP-activated neutrophils evoke histamine release from mast cells. Agents Actions 18:155–158
Feldman EJ, Isenberg JI (1976) Effects of metiamide on gastric acid hypersecretion, steatorrhea and bone-marrow function in a patient with systemic mastrocytosis. N Engl J Med 295:1178–1179
Findlay SR, Dvorak AM, Kagey-Sobotka A, Lichtenstein LM (1981) Hyperosmolar triggering of histamine release from human basophils. J Clin Invest 67:1604–1613
Flaxman BA, Harper RA (1975) In vitro analysis of the control of keratinocyte proliferation in human epidermis by physiologic and pharmacologic agents. J Invest Dermatol 65:52–59
Foreman JC, Lichtenstein LM (1980) Induction of histamine secretion by polycations. Biochim Biophys Acta 629:587–603
Forrest JAH, Shearman DJC, Spence R, Celestin LR (1975) Neutropenia associated with metiamide. Lancet 1:392–393
Galant SP, Allred S, Griffiths R (1980) Characterization of adenylate cyclase activity in asthmatic neutrophil sonicates. Am Rev Respir Dis 122:231–238
Gespach C, Saal F, Cost H, Abita JP (1982) Identification and characterization of surface receptors for histamine in the human promyelocytic leukemia cell line HL-60. Comparison with human peripheral neutrophils. Mol Pharmacol 22: 547–553
Gespach C, Marrec N, Belitrand N (1985a) Relationship between 3H-histamine uptake and H2-receptors in the human promyelocytic leukemia cell line HL-60. Agents Actions 16:279–283
Gespach C, Cost H, Abita J-P (1985b) Histamine H2 receptor activity during the differentiation of the human monocytic-like cell line U-937. Comparison with prostaglandins and isoproterenol. FEBS Lett 184:207–213
Gespach C, Launay J-M, Emami S, Bondoux D, Dreux, C (1986a) Biochemical and pharmacological characterization of histamine-mediated up-regulation of human platelet serotonin uptake. Evidence for a subclass of histamine H2 receptors (H2h) highly sensitive to H2 receptor antagonists. Agents Actions 18:115–119
Gespach C, Courillon-Mallet A, Launay JM, Cost H, Abita J-P (1986b) Histamine H2 receptor activity and histamine metabolism in human U-937 monocyte-like cells and human peripheral monocytes. Agents Actions 18:124–128
Giertz H, Hahn F (1969) Mechanism of histaminase liberation in guinea pig anaphylaxis. Int Arch Allergy Appl Immunol 36:41–44
Giertz H, Hahn F, Krull P, Albert U (1968) Histaminase liberating and anticoagulant activity of heparin released in anaphylactic shock in the guinea-pig. Int Arch Allergy Appl Immunol 33:306–312
Gillespie E, Valentine MD, Lichtenstein LM (1974) Cyclic AMP metabolism in asthma: studies with leukocytes and lymphocytes. J Allergy Clin Immunol 53: 27–33
Glanzmann C, Glanzmann-Zapel I (1971) Histaminasefreisetzung beim Kaninchen durch Heparin, andere Polyanionen und Protamin. Naunyn Schmiedebergs Arch Pharmakol 268:434–445
Gonen B, O’Donnell P, Post TJ, Quinn TJ, Schulman ES (1987) Very low density lipoproteins (VLDL) trigger the release of histamine from human basophils. Biochim Biophys Acta 917:418–424
Goodwin JS, Messner RP, Williams RC Jr (1979) Inhibitors of T-cell mitogenesis: effect of mitogen dose. Cell Immunol 45:303–308
Goth A (1978) On the general problem of the release of histamine. In: Rocha e Silva M (ed) Histamine and anti-histaminics., part II. Springer, Berlin Heidelberg New York, pp 57–74 (Handbuch der experimentellen Pharmakologie, vol 18/2)
Graham HT, Lowry OH, Wheelwright F, Lenz MA, Parish HH Jr (1955) Distribution of histamine among leukocytes and platelets. Blood 10:467–481
Haimart M, Launay JM, Zürcher G, Cauet N, Dreux C, da Prada M (1985) Simultaneous determination of histamine and N-methylhistamine in biological samples by an improved enzymatic single isotope assay. Agents Actions 16:71–75
Harper RA, Flaxman BA, Chopra DP (1974) Mitotic response of normal and psoriatic keratinocytes in vitro to compounds known to affect intracellular cyclic AMP. J Invest Dermatol 62:384–387
Hatamochi A, Fujiwara K, Ueki H (1985) Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Arch Dermatol Res 277: 60–64
Haworth E, MacDonald AD (1937) On histamine in cotton dust, and in the blood of cotton workers. J Hyg 37:234–242
Henderson LL, Code CF, Roth GM (1958) Increased blood histamine in thermal intolerance. Report of a patient with cryoglobulinemia. J Allergy 29:122–129
Henderson WR, Chi EY, Klebanoff SJ (1980) Eosinophil peroxidase-induced mast cell secretion. J Exp Med 152:265–279
Herman JJ, Colten HR (1980) Specific modulation of complement-dependent human granulocyte function by imidazole acetic acid. J Allergy Clin Immunol 66: 274–280
Herman JJ, Brenner JK, Colten HR (1979) Inhibition of histaminase release from human granulocytes by products of histaminase activity. Science 206:77–78
Hill HR, Estensen RD, Quie PG, Hogan NA, Goldberg ND (1975) Modulation of human neutrophil chemotactic responses by cyclic 3′,5′-guanosine monophosphate and cyclic 3′,5′-adenosine monophosphate. Metabolism 24:477–456
Holgate ST, Lewis RA, Austen KF (1980) Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine-and ribose-modified adenosine analogs. Proc Natl Acad Sci USA 77:6800–6804
Horakova Z, Beaven MA (1974) Time course of histamine release and edema formation in the rat paw after thermal injury. Eur J Pharmacol 27:305–312
Horakova Z, Keiser HR, Beaven MA (1977) Blood and urine histamine levels in normal and pathological states as measured by a radiochemical assay. Clin Chim Acta 79:447–456
Hughes PJ, Church MK (1986) Inhibition of immunological and non-immunological histamine release from human basophils by adenosine analogues that act at P-sites. Biochem Pharmacol 35:1809–1816
Hughes PJ, Holgate ST, Roath S, Church HK (1983) The relationship between cyclic AMP changes and histamine release from basophil-rich human leukocytes. Biochem Pharmacol 32:2557–2563
Hughes PJ, Holgate ST, Church MK (1984) Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mechanism. Biochem Pharmacol 33:3847–3852
Humphrey JH, Jaques R (1954) The histamine and serotonin content of the platelets and polymorphonuclear leucocytes of various species. J Physiol (Lond) 124: 305–310
Idvall J (1979) Cimetidine-associated throbocytopenia. Lancet 2:159
Iizuka H, Adachi K, Halprin KM, Levine V (1978) Cyclic AMP accumulation in psoriatic skin: differential responses to histamine, AMP and epinephrine by the uninvolved and involved epidermis. J Invest Dermatol 70:250–253
Imamura I, Watanabe T, Maeyama K, Kubota A, Okada A, Wada H (1984) Effect of food intake on urinary excretions of histamine, Nτ-methylhistamine, imidazole acetic acid and its conjugate(s) in humans and mice. J Biochem 96:1931–1937
Imamura I, Watanabe T, Sakamoto Y, Wakamiya T, Shiba T, Hase Y, Tsuruhara T, Wada H (1985) N-Ribosylation, a novel histidine derivative in urine of his-tidinemic patients. J Biol Chem 260:10526–10530
Johnson NMcI, Black AE, Hughes ASB, Clarke SW (1977) Leucopenia with cimetidine. Lancet 2:1226–1227
Kagey-Sobotka A, Schleimer RP, Peters SP, Lichtenstein LM (1983) Lipoxygenase products release histamine from human basophils. Fed Proc 42:1342
Kahndelwal JK, Hough LB, Morrishow AM, Green JP (1982a) Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine and plasma. Agents Actions 12:583–590
Kahndelwal JK, Hough LB, Pazhenchevsky B, Morrishow AM, Green JP (1982b) Presence and measurement of methylimidazoleacetic acids in brain and body fluids. J Biol Chem 257:12815–12819
Kaliner M, Austen KF (1973) A sequence of biochemical events in the antigen-induced release of chemical mediators from sensitized human lung tissue. J Exp Med 138:1077–1094
Kaplan AP, Gray L, Shaff RE, Horakova Z, Beaven MA (1975) In vivo studies of mediator release in cold urticaria and cholinergic urticaria. J Allergy Clin Immunol 55:394–402
Keyzer JJ, Wolthers BG, Muskiet FAJ, Breukelman H, Kauffman HF, de Vries K (1984) Measurement of plasma histamine by stable isotope dilution gas chromatography-mass spectrometry: methodology and normal values. Anal Biochem 139:474–481
Khan MM, Melmon KL, Fathman CG, Hertel-Wulff B, Strober S (1985) The effects of autacoids on cloned murine lymphoid cells: modulation of IL-2 secretion and the activity of natural suppressor cells. J Immunol 134:4100–4106
Kimura I, Tanizaki Y, Sato S, Takahasi K (1981) Differences in response to anti-IgE and to anti-IgG in basophils from patients with bronchial asthma. Clin Allergy 11:31–36
Klotz SA, Kay BF (1978) Cimetidine and agranulocytosis. Ann Intern Med 88: 579–580
Kobayashi Y, Kupelian J, Maudsley DV (1969) Release of diamine oxidase by heparin in the rat. Biochem Pharmacol 18:1585–1591
Konoshita K (1963) Studies on histamine in the blood of children. III. On histamine in the blood in allergic diseases. Acta Paediatr Jpn 67:675–679
Krauss S, Gilbert HS, Wassermann LR (1968) Leukocyte histidine decarboxylase: properties and activity in myeloproliferative disorders. Blood 31:699–709
Lai KH, Cho CH, Ogle CW, Wang JY (1986) Effects of eight-week treatment with histamine H2-antagonists or an antacid on plasma levels of histamine and serotonin in duodenal ulcer patients. Pharmacol Res Commun 18:807–812
Lappin D, Whaley K (1980) Effects of histamine on monocyte complement production. I. Inhibition of C2 production mediated by its actions on H2-receptors. Clin Exp Immunol 41:497–504
Lett-Brown MA, Leonard EJ (1977) Histamine-induced inhibition of normal human basophil chemotaxis to C5a. J Immunol 118:815–818
Lichtenstein LM, Gillespie E (1973) Inhibition of histamine release by histamine is controlled by an H2-receptor. Nature 244:287–288
Lin C-W, Inglis NR, Rule AH, Turksoy RN, Chapman CM, Kirley SD, Stolbach LL (1979) Histamine and other tumor markers in malignant effusion fluids. Cancer Res 39:4894–4899
Londos C, Wolff J (1977) Two distinct adenosine-sensitive sites on adenylate cyclase. Proc Natl Acad Sci USA 74:5482–5486
Lorenz W, Thermann M, Messmer K, Schmal A, Dormann P, Kusche J, Barth H, Tauber R, Hutzel M, Mann G, Uhlig R (1974) Evaluation of histamine elimination curves in plasma and whole blood of several circulatory regions: a method for studying kinetics of histamine release in the whole animal. Agents Actions 4: 336–356
Macquin I, Harf A, Zerah F, Sabatier C, Lhoste F (1985) Bronchorelaxation and plasma histamine after salbutamol inhalation. Eur J Clin Pharmacol 28:631–636
Marks RM, Roche WR, Czerniecki M, Penny R, Nelson DS (1986) Mast cell granules cause proliferation of human micro vascular endothelial cells. Lab Invest 55: 289–294
Marone G, Kagey-Sobotka A, Lichtenstein LM (1979) Effects of arachidonic acid and its metabolites on antigen-induced histamine release from human basophils in vitro. J Immunol 123:1669–1677
Marone G, Thomas LL, Lichtenstein LM (1980) The role of agonists which activate adenylate cyclase in the control of cAMP metabolism and enzyme release by human polymorphonuclear leukocytes. J Immunol 125:2277–2283
Marone G, Kagey-Sobotka A, Lichtenstein LM (1981) IgE-mediated histamine release from human basophils: differences between antigen E- and anti-IgE- induced secretion. Int Archs Allergy Appl Immunol 65:339–348
Marone G, Columbo M, Triggiani M, Cirillo R, Genovese A, Formisano S (1987) Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. Biochem Pharmacol 36:13–20
Maśliński CZ, Kierska D, Sasiak K, Adamas B (1984) Histamine and its catabolism in tumour-bearing rat and mouse. Agents Actions 14:497–500
Matsui M (1982) A study on the control of blood levels of histamine by intravenous administration of steroids and synthetic ACTH in patients with bronchial asthma. Arerugi 31:141–150
Mayer P, Lam C, Obenaus H, Liehl E, Besemer J (1987) Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in nonhuman primates. Blood 70:206–213
McGivney A, Morita Y, Crews FT, Hirata F, Axelrod J, Siraganian RP (1981) Phospholipase activation in the IgE-mediated and Ca2+ ionophore A23187-induced release of histamine from rat basophilic leukemia cells. Arch Biochem Biophys 212:572–580
Melmon KL, Khan MM (1987) Histamine and its lymphocyte-selective derivatives as immune modulators. Trends Pharmacol Sci 8:437–441
Melmon KL, Bourne HR, Weinstein Y, Shearer GM, Kram J, Bauminger S (1974) Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones. J Clin Invest 53:13–21
Mendelsohn G, Eggleston JC, Weisburger WR, Gann DS, Baylin SB (1978) Calcitonin and histaminase in C-cell hyperplasia and medullary thyroid carcinoma. A light microscopic and immunohistochemical study. Am J Pathol 92:35–52
Miadonna A, Tedeschi A, Leggieri E, Lorini M, Froldi M, Zanussi C (1986) Effect of calcium antagonists on histamine release from human basophil leukocytes. Br J Clin Pharmacol 22:483–486
Mita H, Yui Y, Yasueda H, Shida T (1987) Quantitation of histamine by radioimmunoassay. Arerugi 36:121–129
Mitchell RG, Cass R (1959) Histamine and 5-hydroxytryptamine in the blood of infants and children. J Clin Invest 38:595–604
Mitchell RG, Porter JF (1970) Histamine and granulocytes in the umbilical cord blood of infants at birth. Br J Pharmacol 40:310–316
Morgan DJR, Moodley I, Phillips MJ, Davies RJ (1983) Plasma histamine in asthmatic and control subjects following exercise: influence of circulating basophils and different assay techniques. Thorax 38:771–777
Nakaya N, Tasaka K (1988a) Histamine incorporation into murine myeloblasts and promyelocytes. Formation of a histamine transport system. Biochem Pharmacol 37:4523–4530
Nakaya N, Tasaka K (1988b) The influence of histamine on precursors of granulocytic leukocytes in murine bone marrow. Life Sci 42:999–1010
Noah JW, Brand A (1957) The effect of corticosteroid administration upon blood histamine content. J Allergy 28:405–413
Ogasawara H, Fujitani T, Drzewiecki G, Middleton E (1986) The role of hydrogen peroxide in basophil histamine release and the effect of selected flavonoids. J Allergy Clin Immunol 78:321–328
Okuda Y, Tsuyuguchi I, Yamatodani A (1988) Histamine release from human leukocytes by platelet-activating factor. Int Arch Allergy Appl Immunol 85:341–345
Ozaki Y, Kume S, Ohashi T (1984) Effects of histamine agonists and antagonists on luminol-dependent chemiluminescence of granulocytes. Agents Actions 15: 182–188
Parker CW, Smith JW (1973) Alerations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to β-adrenergic agents. J Clin Invest 52:48–59
Parwaresch MR (1976) The human blood basophil. Springer, Berlin Heidelberg New York
Peters SP, Kagey-Sobotka A, MacGlashan DW Jr, Siegel MI, Lichtenstein LM (1982) The modulation of human basophil histamine release by products of the 5-lipoxygenase pathway. J Immunol 129:797–803
Peyret LM, Moreau P, Dulluc J, Geffard M (1986) Antibodies to histamine. Specificity studies and radioimmunological assay. J Immunol Methods 90:39–45
Pincus SH (1978) Production of eosinophil-rich guinea pig peritoneal exudates. Blood 52:127–134
Pincus SH, DiNapoli A-M, Schooley WR (1982) Superoxide production by eosinophils: activation by histamine. J Invest Dermatol 79:53–57
Plaut M, Lichtenstein LM (1982) Histamine and immune responses. In: Ganellin CR, Parsons ME (eds) Pharmacology of histamine receptors, Wright, Oxford, pp 392–435
Plaut M, Lichtenstein LM, Gillespie E, Henny CS (1973) Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells. J Immunol 111:389–394
Plaut M, Kagey-Sobotka A, Jacques AR (1985) Modulation of cytotoxic T lymphocyte responses by histamine. In: Ganellin CR, Schwartz J-C (eds) Frontiers in histamine Research. Pergamon, Oxford, pp 379–388
Pommier de Santi P, Vervloet D, Vellienx P, Payan H, Charpin J (1978) Electron microscopic study of the anaphylactic degranulation of human basophils from atopic subjects. Int Arch Allergy Appl Immunol 57:462–471
Porter JF, Mitchell RG (1970) The distribution of histamine in the blood of healthy and asthmatic children. Clin Sci 38:135–143
Porter JF, Mitchell RG (1972) Distribution of histamine in human blood. Physiol Rev 52:361–381
Pruzansky JJ, Zeiss CR, Patterson R (1980) A linear correlation between histamine release and degranulation of human basophils by specific antigen or the ionophore A23187. Immunology 40:411–416
Radermecker M, Maldague M-P (1981) Depression of neutrophil chemotaxis in atopic individuals. An H2 histamine receptor response. Int Arch Allergy Appl Immunol 65:144–152
Rehn D, Reimann HJ, von der Ohe M, Schmidt U, Schmal A, Hennings G (1987) Biorhythmic changes of plasma histamine levels in healthy volunteers. Agents Actions 22:24–29
Riley JF (1959) The mast cells. Livingstone, Edinburgh
Riley JF, West GB (1953) The presence of histamine in tissue mast cells. J Physiol (Lond) 120:528–537
Ring J, O’Connor R (1979) In vitro histamine and serotonin release studies in atopic dermatitis. Int Arch Allergy Appl Immunol 58:322–330
Rocklin RE (1976) Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. J Clin Invest 57:1051–1058
Rocklin RE (1985) Histamine-induced suppressor cell responses in normal and atopic subjects. In: Ganellin CR, Schwartz J-C (eds) Frontiers in histamine research, Pergamon, Oxford, pp 357–364
Rocklin RE, Haberek-Davidson A (1981) Histamine activates suppressor cells in vitro using a coculture technique. J Clin Immunol 1:73–79
Rocklin RE, Greineder D, Melmon KL (1979) Histamine-induced suppressor factor (HSF): further studies on the nature of the stimulus and the cell which produces it. Cell Immunol 44:404–415
Roder JC, Klein M (1979) Target-effector interaction in the natural killer cell system. IV. Modulation by cyclic nucleotides. J Immunol 123:2785–2790
Rose B, Browne JSL (1940) Alterations in the blood histamine in shock. Proc Soc Exp Biol Med 44:182–188
Rose B, Weil P (1939) Blood histamine in the rabbit during anaphylactic shock. Proc Soc Exp Biol Med 42:494–496
Rose B, Rusted I, Fownes JA (1950) Intravascular catheterization studies of bronchial asthma. I. Histamine levels in arterial and mixed venous blood of asthmatic patients before and during induced attacks. J Clin Invest 29:1113–1119
Rothenberg ME, Caulfield JP, Austen KF, Hein A, Edmiston K, Newburger PE, Stevens RL (1987) Biochemical and morphological characterization of basophilic leukocytes from two patients with myelogenous leukemia. J Immunol 138: 2616–2625
Sampson D, Archer GT (1967) Release of histamine from human basophils. Blood 29:722–736
Sansoni P, Silverman ED, Khan MM, Melmon KL, Engleman EG (1985) Immuno-regulatory T cells in man. Histamine-induced suppressor T cells are derived from a Leu2+ (T8+) subpopulation distinct from that which gives rise to cytotoxic T cells. J Clin Invest 75:650–656
Sawutz DG, Kalinyak K, Whitsett JA, Johnson CL (1984) Histamine H2-receptor desensitization in HL-60 human promyelocytic leukemia cells. J Pharmacol Exp Ther 231:1–7
Schayer RW (1966) Catabolism of histamine in vivo. In: Rocha e Silva M (ed) Histamine and antihistaminics, part I. Springer, Berlin Heidelberg New York, pp 672–683 (Handbuch der experimentellen Pharmakologie, vol 18/1)
Schleimer RP, Gillespie E, Daiuta R, Lichtenstein LM (1982) Release of histamine from human leukocytes stimulated with the tumour-promoting phorbol diesters. II. Interaction with other stimuli. J Immunol 128:136–140
Schmutzler W, Hahn F, Goldschmidt O, Seseke G (1966) Untersuchungen über Substanzen mit histaminaselieberierender Wirkung beim Meerschweinchen. Naunyn Schmiedebergs Arch Pharmakol Exp Pathol 255:344–352
Schmutzler W, Goldschmidt O, Bethge KP, Knop J (1969) The release of guinea pig liver histaminase and some of its properties. Int Arch Allergy Appl Immunol 36:45–55
Schulman ES, MacGlashan DW, Peters SP, Schleimer RP, Newball HH, Lichtenstein LM (1982) Human lung mast cells: purification and characterization. J Immunol 129:2662–2667
Schwartz A, Askenase PW, Gershon RK (1980) Histamine inhibition of the in vitro induction of cytotoxic T-cell responses. Immunopharmacology 2:179–190
Sessa A, Desiderio MA, Perin A (1987) Effect of acute ethanol administration on diamine oxidase activity in maternal, embryonal and fetal tissues. Agents Actions 21:49–53
Shaff RE, Beaven MA (1979) Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum. Anal Biochem 94: 425–430
Shimkin MB, Sapirstein L, Goetzl FR, Wheeler PM, Berlin NI (1949) Blood histamine in leukemia and erythermia. JNCI 9:379–387
Shimkin MB, Bierman HR, Low-Beer BVA, Wheeler PM, Goetzl FR (1951) Blood histamine in myelogenous leukemia. Cancer 4:570–578
Shore PA, Burkhalter A, Cohn VH Jr (1959) A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther 127:182–186
Siraganian RP, Hook WA (1976) Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction. J Immunol 116: 639–646
Smith RJ, Iden SS (1979) Phorbol myristate-acetate induced release of granule enzymes from human neutrophils: inhibition by the calcium antagonist 8-(N, N-diethylamine)-ocytl 3,4,5-trimethoxybenzoate hydrochloride. Biochem Biophys Res Commun 91:263–271
Snyder SH, Baldessarini RJ, Axelrod J (1966) A sensitive and specific enzymatic isotopic assay for tissue histamine. J Pharmacol Exp Ther 153:544–549
Spall RD, Ainsworth SK (1978) Serum histamine levels following administration of ultrastructural tracers in three strains of rats. Agents Actions 8:206–208
Stewart J, Jones DG, Kay AB (1979) Metabolic studies on the uptake of [14C]-histidine and [14C]-histamine and histamine synthesis by guinea-pig basophils, in vitro. Immunology 36:539–548
Subramanian N, Bray MA (1987) Interleukin 1 releases histamine from human basophils and mast cells in vitro. J Immunol 138:271–275
Swahn CG, Sedvall G (1983) Identification and determination of 1-methylimidazole-4-acetic acid in human cerebrospinal fluid by gas chromatography-mass spectrometry. J Neurochem 40:688–696
Tanizaki Y, Komagoe H, Sudo M, Morinaga H, Kitani H, Tada S, Takahashi K, Kimura I (1984) Blood eosinophilia in bronchial asthma and its relationship to IgE-mediated reactions. Acta Med Okayama 38:525–531
Tarnok I, Tarnok Z (1987) Interaction of cimetidine and histamine with superoxide generated in a cell-free system and in neutrophils. Agents Actions 20:324–326
Tasaka K, Code CF (1964) Histamine leukocytosis. Fed Proc 23:471
Tasaka K, Nakaya N (1987) The relationship between incorporation of histamine and differentiation of neutrophil progenitors in murine bone marrow. Agents Actions 20:320–323
Ting S, Dunsky EH, Zweiman B (1980) Histamine suppression of eosinophilotaxis and histamine release in vivo. J Allergy Clin Immunol 65:196–197
Tsuruta Y, Kohashi K, Ohkura Y (1978) Determination of histamine in plasma by high-speed liquid chromatography. J Chromatogr 146:490–493
Tung R, Kagey-Sobotka A, Plaut M, Lichtenstein LM (1982) H2 anti-histamines augment antigen-induced histamine release from human basophils in vitro. J Immunol 129:2113–2115
Turnbull LW, Kay AB (1976) Eosinophils and mediators of anaphylaxis. Histamine and imidazole acetic acid as chemotactic agents for human eosinophil leucocytes. Immunology 31:797–802
Turnbull LW, Evans DP, Kay AB (1977) Human eosinophils, acidic tetrapeptides (ECF-A) and histamine. Interactions in vitro and in vivo. Immunology 32:57–63
Valone FH (1980) Modulation of human neutrophil and eosinophil polymorphonuclear leukocyte chemotaxis: an analytical review. Clin Immunol Immunophathol 15:52–65
Vickers MR, Milliner K, Martin D, Ganellin CR (1982) Histamine-induced inhibition of lymphocyte proliferation and lysosomal enzyme release from polymorphs may not be mediated via H1- or H2-receptors. Agents Actions 12:630–634
Voorhees JJ, Duell EA, Bass LJ, Powell JA, Harrell ER (1972) The cyclic AMP system in normal and psoriatic epidermis. J Invest Dermatol 59:114–120
Waddee AA, Anderson R, Sher R (1980) In vitro effects of histamine on eosinophil migration. Int Arch Allergy Appl Immunol 63:322–329
Wardlaw AJ, Moqbel R, Cromwell O, Kay AB (1986) Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. J Clin Invest 78:1701–1706
Yamada S, Mayahara T, Wakabayashi K, Nakamura T, Maruyama I, Maruyama S (1976) Distribution of histamine in tissues of four species of animals as determined by fluorometry; a comparison of bioassay and fluorometry in tissue histamine content. Pharmacometrics 12:579–584
Zeiger RS, Colten HR (1977) Histaminase release from human eosinophils. J Immunol 118:540–543
Zeiger RS, Yurdin DL, Colten HR (1976) Histamine metabolism. II. Cellular and subcellular localization of the catabolic enzymes, histamine and histamine methyl transferase, in human leukocytes. J Allergy Clin Immunol 58:172–179
Zetter BR, Rasmussen N, Brown L (1985) An in vivo assay for chemoattractant activity. Lab Invest 53:362–368
Zimmermann I, Bugalho de Almeida AA, Ulmer WT (1980) Allergeninduzierte Atemwegsobstruktion und Histaminkonzentration im arteriellen wie venösen Plasma. Res Exp Med 177:91–100
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Tasaka, K. (1991). Histamine and the Blood. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_23
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