Cardiac Glycosides

Part II: Pharmacokinetics and Clinical Pharmacology

  • Kurt Greeff

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 56 / 2)

Table of contents

  1. Front Matter
    Pages I-XXI
  2. Pharmacokinetics — Distribution, Metabolism, and Elimination

    1. Front Matter
      Pages 1-1
    2. Liv Storstein
      Pages 3-30
    3. N. Rietbrock, B. G. Woodcock
      Pages 31-56
    4. K. Greeff, K. E. Wirth
      Pages 57-85
    5. K.-E. Andersson, B. Bergdahl
      Pages 87-94
  3. Pharmacokinetics — Additional Pharmacokinetic Parameters of Cardiac Glycosides

  4. Clinical Pharmacology

  5. Back Matter
    Pages 337-396

About this book

Introduction

The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.

Keywords

absorption kinetics pharmacokinetics research

Editors and affiliations

  • Kurt Greeff
    • 1
  1. 1.Instituts für PharmakologieUniversität DüsseldorfDüsseldorfDeutschland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68166-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68168-4
  • Online ISBN 978-3-642-68166-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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