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Pharmacokinetics of Digoxin and Derivatives

  • N. Rietbrock
  • B. G. Woodcock
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 56 / 2)

Abstract

In the absence of sensitive analytical methods, estimation of the quantity of glycoside in the myocardium was at one time possible only by observing the pharmacologic effect in the intact animal, or in a heart—lung preparation, or in the embryonic chick heart (Weese, 1928, 1929; Lendle, 1935; Rothlin, 1944; Friedman and Bine, 1947; Bine et al., 1951; Rothlin and Bircher, 1954). Later, the direct detection of digitalis glycosides in various organs and tissues of the rat was achieved using the xanthydrol or m-dinitrobenzol reaction (Repke, 1958). Fluorescence techniques enabled additional inferences on the structure of the steroid nucleus to be obtained (Jensen, 1953; Wells et al., 1961; Jelliffe, 1967). The main disadvantage of the foregoing methods is the relatively low sensitivity.

Keywords

Creatinine Clearance Renal Excretion Cardiac Glycoside Urine Flow Rate Digoxin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • N. Rietbrock
  • B. G. Woodcock

There are no affiliations available

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