Phosphodiesterases as Drug Targets

  • Sharron H. Francis
  • Marco Conti
  • Miles D. Houslay

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 204)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Christian Schudt, Armin Hatzelmann, Rolf Beume, Hermann Tenor
    Pages 1-46
  3. Sharron H. Francis, Miles D. Houslay, Marco Conti
    Pages 47-84
  4. Hermann Tenor, Armin Hatzelmann, Rolf Beume, Gezim Lahu, Karl Zech, Thomas D. Bethke
    Pages 85-119
  5. Hengming Ke, Huanchen Wang, Mengchun Ye
    Pages 121-134
  6. Didem Demirbas, Ozge Ceyhan, Arlene R. Wyman, Charles S. Hoffman
    Pages 135-149
  7. Joachim E. Schultz, Torsten Dunkern, Elvira Gawlitta-Gorka, Gabriele Sorg
    Pages 151-166
  8. Mark E. Gurney, Alex B. Burgin, Olafur T. Magnusson, Lance J. Stewart
    Pages 167-192
  9. Yongge Liu, Yasmin Shakur, Junichi Kambayashi
    Pages 211-236
  10. Matthew A. Movsesian, Rakesh C. Kukreja
    Pages 237-249
  11. F. Murray, M. R. MacLean, P. A. Insel
    Pages 279-305
  12. Justin M. Percival, Candace M. Adamo, Joseph A. Beavo, Stanley C. Froehner
    Pages 323-344
  13. Elisa Bjørgo, Kristine Moltu, Kjetil Taskén
    Pages 345-363
  14. Angie L. Hertz, Joseph A. Beavo
    Pages 365-390

About this book

Introduction

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Keywords

cAMP cGMP inhibitors medicinal chemistry phosphodiesterases signaling

Editors and affiliations

  • Sharron H. Francis
    • 1
  • Marco Conti
    • 2
  • Miles D. Houslay
    • 3
  1. 1.School of Medicine, Dept. Molecular Physiology & BiophysicsVanderbilt UniversityNashvilleUSA
  2. 2.HSW 1656Center for Reproductive SciencesSan FranciscoUSA
  3. 3.Wolfson BuildingUniversity of GlasgowGlasgowUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-17969-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-17968-6
  • Online ISBN 978-3-642-17969-3
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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