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Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders

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Phosphodiesterases as Drug Targets

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 204))

Abstract

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes that are involved in the regulation of the intracellular second messengers cyclic AMP (cAMP) and cyclic GMP (cGMP) by controlling their rates of hydrolysis. There are 11 different PDE families and each family typically has multiple isoforms and splice variants. The PDEs differ in their structures, distribution, modes of regulation, and sensitivity to inhibitors. Since PDEs have been shown to play distinct roles in processes of emotion and related learning and memory processes, selective PDE inhibitors, by preventing the breakdown of cAMP and/or cGMP, modulate mood and related cognitive activity. This review discusses the current state and future development in the burgeoning field of PDEs in the central nervous system. It is becoming increasingly clear that PDE inhibitors have therapeutic potential for the treatment of neuropsychiatric disorders involving disturbances of mood, emotion, and cognition.

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Authors and Affiliations

  1. Departments of Behavioral Medicine & Psychiatry, Neurobiology & Anatomy, and Physiology & Pharmacology and the WVU Center for Neuroscience, West Virginia University Health Sciences Center, WVU HSC/School of Medicine, Morgantown, 9104, WV, 26506, USA

    Ying Xu, Han-Ting Zhang & James M. O’Donnell

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  1. Ying Xu
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  2. Han-Ting Zhang
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  3. James M. O’Donnell
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Correspondence to James M. O’Donnell .

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Editors and Affiliations

  1. School of Medicine, Dept. Molecular Physiology & Biophysics, Vanderbilt University, Light Hall 702, Nashville, 37232-0615, Tennessee, USA

    Sharron H. Francis

  2. HSW 1656, Center for Reproductive Sciences, Parnassus Avenue 513, San Francisco, 94143-0556, California, USA

    Marco Conti

  3. Wolfson Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom

    Miles D. Houslay

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Xu, Y., Zhang, HT., O’Donnell, J.M. (2011). Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders. In: Francis, S., Conti, M., Houslay, M. (eds) Phosphodiesterases as Drug Targets. Handbook of Experimental Pharmacology, vol 204. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17969-3_19

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