Pharmacology of Neurotransmitter Release

  • Thomas C. Südhof
  • Klaus Starke

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 184)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Thomas C. Süudhof
    Pages 1-21
  3. Mikhail Khvotchev, Ege T. Kavalali
    Pages 23-43
  4. Alexandra E. Kisilevsky, Gerald W. Zamponi
    Pages 45-75
  5. Farrukh A. Chaudhry, Jean-Luc Boulland, Monica Jenstad, May K. L. Bredahl, Robert H. Edwards
    Pages 77-106
  6. Thorsten Lang, Reinhard Jahn
    Pages 107-127
  7. Ornella Rossetto, Cesare Montecucco
    Pages 129-170
  8. Yuri A. Ushkaryov, Alexis Rohou, Shuzo Sugita
    Pages 171-206
  9. David A. Brown, Talvinder S. Sihra
    Pages 207-260
  10. Jorge Gonçalves, Glória Queiroz
    Pages 339-372
  11. E. Schlicker, M. Kathmann
    Pages 409-434
  12. David M. Lovinger
    Pages 435-477
  13. M. M. Dorostkar, S. Boehm
    Pages 479-527
  14. Robert Feil, Thomas Kleppisch
    Pages 529-560
  15. S. Z. Langer
    Pages 561-573
  16. Back Matter
    Pages 575-582

About this book

Introduction

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book’s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.

Keywords

Cannabinoid Exocytosis Neurotransmitter Release Presynaptic autoreceptors Synaptic plasticity adenosine dopamine

Editors and affiliations

  • Thomas C. Südhof
    • 1
  • Klaus Starke
    • 2
  1. 1.Howard Hughes Medical Institute and Center for Basic NeuroscienceUT Southwestern Medical CenterDallasUSA
  2. 2.Institut für Experimentelle und Klinische Pharmakologie und ToxikologieAlbert-Ludwigs-Universität FreiburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-74805-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-74804-5
  • Online ISBN 978-3-540-74805-2
  • Series Print ISSN 0171-2004
  • About this book
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