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Pharmacology of Neurotransmitter Release pp 129–170Cite as

Presynaptic Neurotoxins with Enzymatic Activities

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 184))

Toxins that alter neurotransmitter release from nerve terminals are of considerable scientific and clinical importance. Many advances were recently made in the understanding of their molecular mechanisms of action and use in human therapy. Here, we focus on presynaptic neurotoxins, which are very potent inhibitors of the neurotransmitter release because they are endowed with specific enzymatic activities: (1) clostridial neurotoxins with a metallo-proteolytic activity and (2) snake presynaptic neurotoxins with a phospholipase A2 activity.

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  1. Departimento de Scienze Biomediche and Istituto CNR di Neuroscienze, Universit`a di Padova, Viale G. Colombo 3, 35121, Padova, Italy

    Ornella Rossetto & Cesare Montecucco

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  1. Ornella Rossetto
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  2. Cesare Montecucco
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  1. Howard Hughes Medical Institute and Center for Basic Neuroscience, UT Southwestern Medical Center, 6000 Harry Hines Blvd. NA4.118, Dallas, TX 75390, USA

    Thomas C. Südhof

  2. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 25, D-79104 Freiburg i.Br., Germany

    K. Starke  & Klaus Starke  & 

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Rossetto, O., Montecucco, C. (2008). Presynaptic Neurotoxins with Enzymatic Activities. In: Südhof, T.C., Starke, K. (eds) Pharmacology of Neurotransmitter Release. Handbook of Experimental Pharmacology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74805-2_6

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