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Presynaptic Adenosine and P2Y Receptors

  • Chapter
Pharmacology of Neurotransmitter Release

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 184))

Adenine-based purines, such as adenosine and ATP, are ubiquitous molecules that, in addition to their roles in metabolism, act as modulators of neurotransmitter release through activation of presynaptic P1 purinoceptors or adenosine receptors (activated by adenosine) and P2 receptors (activated by nucleotides). Of the latter, the P2Y receptors are G protein-coupled, whereas the P2X receptors are ligand-gated ion channels and not covered in this review.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Porto, Porto, Portugal

    Jorge Gonçalves (Faculty of Pharmacy) & Glória Queiroz (Faculty of Pharmacy)

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  1. Jorge Gonçalves
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  2. Glória Queiroz
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Editors and Affiliations

  1. Howard Hughes Medical Institute and Center for Basic Neuroscience, UT Southwestern Medical Center, 6000 Harry Hines Blvd. NA4.118, Dallas, TX 75390, USA

    Thomas C. Südhof

  2. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 25, D-79104 Freiburg i.Br., Germany

    K. Starke  & Klaus Starke  & 

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Gonçalves, J., Queiroz, G. (2008). Presynaptic Adenosine and P2Y Receptors. In: Südhof, T.C., Starke, K. (eds) Pharmacology of Neurotransmitter Release. Handbook of Experimental Pharmacology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74805-2_11

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