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Plasma Cell Dyscrasias

  • Aldo M. Roccaro
  • Irene M. Ghobrial

Part of the Cancer Treatment and Research book series (CTAR, volume 169)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Monoclonal Gammopathy of Undetermined Significance and Smoldering Myeloma

    1. Front Matter
      Pages 1-1
    2. María-Victoria Mateos, Ola Landgren
      Pages 3-12
  3. Multiple Myeloma

    1. Front Matter
      Pages 13-13
    2. Salomon Manier, Karma Salem, Siobhan V. Glavey, Aldo M. Roccaro, Irene M. Ghobrial
      Pages 23-34
    3. Siobhan V. Glavey, Salomon Manier, Antonio Sacco, Karma Salem, Yawara Kawano, Juliette Bouyssou et al.
      Pages 35-49
    4. Michele Moschetta, Yawara Kawano, Klaus Podar
      Pages 63-102
    5. Bruno Paiva, Ramón García-Sanz, Jesús F. San Miguel
      Pages 103-122
    6. Guillemette Fouquet, Francesca Gay, Eileen Boyle, Sara Bringhen, Alessandra Larocca, Thierry Facon et al.
      Pages 123-143
    7. Paola Neri, Nizar J. Bahlis, Claudia Paba-Prada, Paul Richardson
      Pages 169-194
    8. Sagar Lonial
      Pages 195-205
    9. Yogesh S. Jethava, Frits van Rhee
      Pages 227-250
    10. Homare Eda, Loredana Santo, G. David Roodman, Noopur Raje
      Pages 251-270
  4. Primary Amyloidosis, Systemic Light Chain and Heavy Chain Diseases, Plasmacytoma

    1. Front Matter
      Pages 271-271
    2. Angela Dispenzieri, Giampaolo Merlini
      Pages 273-318
  5. Waldenstrom’s Macroglobulinemia

    1. Front Matter
      Pages 319-319
    2. Prashant Kapoor, Stephen M. Ansell, Esteban Braggio
      Pages 321-361

About this book

Introduction

This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.

Keywords

Bone marrow microenvironment Genetics Multiple Myeloma Plasma cell dyscrasias Therapies

Editors and affiliations

  • Aldo M. Roccaro
    • 1
  • Irene M. Ghobrial
    • 2
  1. 1.Dept. of Medical Oncolgy/Hematology,ASST-Spedali Civili di Brescia Dept. of Medical Oncolgy/Hematology,BresciaItaly
  2. 2.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-40320-5
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-40318-2
  • Online ISBN 978-3-319-40320-5
  • Series Print ISSN 0927-3042
  • Series Online ISSN 2509-8497
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology