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Molecular Toxicology Protocols

  • Phouthone Keohavong
  • Stephen G. Grant

Part of the Methods in Molecular Biology book series (MIMB, volume 1105)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Toxicoproteomics

    1. Front Matter
      Pages 1-1
    2. Katie Partyka, Shuangshuang Wang, Ping Zhao, Brian Cao, Brian Haab
      Pages 3-15
  3. Toxicant-Induced Inflammation

  4. Gene Promoter Methylation

  5. Array Technologies

    1. Front Matter
      Pages 83-83
    2. Kaori Shintani-Ishida, Bao-Li Zhu, Hitoshi Maeda
      Pages 117-124
  6. Analysis of DNA Adducts

    1. Front Matter
      Pages 125-125
    2. David H. Phillips, Volker M. Arlt
      Pages 127-138
    3. Karen H. Dingley, Esther A. Ubick, John S. Vogel, Ted J. Ognibene, Michael A. Malfatti, Kristen Kulp et al.
      Pages 147-157
    4. Walter A. Deutsch, Vijay Hegde
      Pages 159-168
  7. Detection of Chromosomal and Genome-Wide Damage

  8. Detection and Characterization of Surrogate Gene Mutation

  9. Detection and Characterization of Cancer Gene Mutation

    1. Front Matter
      Pages 313-313
    2. Therese Sørlie, Hilde Johnsen, Phuong Vu, Guro Elisabeth Lind, Ragnhild Lothe, Anne-Lise Børresen-Dale
      Pages 315-324
    3. Meagan B. Myers, Page B. McKinzie, Yiying Wang, Fanxue Meng, Barbara L. Parsons
      Pages 345-363
    4. Vibhuti Gupta, Reetakshi Arora, Sailesh Gochhait, Narendra K. Bairwa, Rameshwar N. K. Bamezai
      Pages 365-380
  10. Analysis of DNA Damage and Repair Mechanisms

    1. Front Matter
      Pages 417-417
    2. Amy Furda, Janine H. Santos, Joel N. Meyer, Bennett Van Houten
      Pages 419-437
    3. Dawn M. Stults, Michael W. Killen, Andrew J. Pierce
      Pages 439-455
    4. Michael W. Killen, Dawn M. Stults, Andrew J. Pierce
      Pages 457-479
    5. Andrew J. Pierce, Maria Jasin
      Pages 481-495
    6. Narendra K. Bairwa, Anjana Saha, Sailesh Gochhait, Ranjana Pal, Vibhuti Gupta, Rameshwar N. K. Bamezai
      Pages 497-509
    7. Petra Pfeiffer, Andrea Odersky, Wolfgang Goedecke, Steffi Kuhfittig-Kulle
      Pages 565-585
  11. Analysis of Cellular Bioenergetics and Apoptosis

    1. Front Matter
      Pages 587-587

About this book

Introduction

Molecular Toxicology Protocols, Second Edition aims to bring together a series of articles describing validated methods to elucidate specific molecular aspects of toxicology, the emphasis being on the application of molecular methods to genetic toxicology. The volume is divided into ten parts, roughly corresponding to the spectrum of biomarkers intermediate between exposure and disease outcomes as proposed in molecular epidemiology models. Subjects of these new chapters range from preparation of fluid specimens for analysis of cellular inflammatory responses to genotoxic insults to sensitive methods for proteomic analysis and aberrant DNA methylation patterns. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, Molecular Toxicology Protocols, Second Edition addresses not only the needs of molecular biologists and toxicologists, but also those of individuals interested in applying molecular methods to clinical applications, such as geneticists, pathologists, biochemists, and epidemiologists. 

Keywords

DNA adducts DNA methylation array technology gene mutation toxicoproteomics

Editors and affiliations

  • Phouthone Keohavong
    • 1
  • Stephen G. Grant
    • 2
  1. 1.Occupational HealthUniversity of Pittsburgh Dept. Environmental &PittsburghUSA
  2. 2.Dept. of Pharmaceutical SciencesNova Southeastern University College of PharmacyFort LauderdaleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-739-6
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-738-9
  • Online ISBN 978-1-62703-739-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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