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Peptide-Based Drug Design

  • Laszlo Otvos

Part of the Methods In Molecular Biology™ book series (MIMB, volume 494)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Laszlo Otvos Jr.
    Pages 1-8
  3. Christin Stegemann, Ralf Hoffmann
    Pages 31-46
  4. Eleni Giannakis, Lin-Wai Hung, Keyla Perez Camacaro, David P. Smith, Kevin J. Barnham, John D. Wade
    Pages 71-86
  5. Jan-Christoph Westermann, David J. Craik
    Pages 87-113
  6. Jeffrey Copps, Richard F. Murphy, Sandor Lovas
    Pages 115-126
  7. Kai Hilpert, Christopher D. Fjell, Artem Cherkasov
    Pages 127-159
  8. Håvard Jenssen, Stein Ivar Aspmo
    Pages 177-186
  9. David Singer, Ralf Hoffmann
    Pages 209-222
  10. Predrag Cudic, Maciej Stawikowski
    Pages 223-246
  11. Brendon Y. Chua, Weiguang Zeng, David C. Jackson
    Pages 247-261
  12. Marina V. Backer, Zoia Levashova, Richard Levenson, Francis G. Blankenberg, Joseph M. Backer
    Pages 275-294
  13. Back Matter
    Pages 295-303

About this book

Introduction

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.

Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Keywords

Amino acid Bioactive proteins Drug development Peptide chemistry Peptide sequences

Editors and affiliations

  • Laszlo Otvos
    • 1
  1. 1.Center for BiotechnologyTemple UniversityPhiladelphia

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-419-3
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-990-1
  • Online ISBN 978-1-59745-419-3
  • Series Print ISSN 1064-3745
  • Buy this book on publisher's site
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