Overview
- Editors:
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William B. Coleman
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Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA
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Gregory J. Tsongalis
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Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA
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Table of contents (24 chapters)
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Introduction
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- William B. Coleman, Gregory J. Tsongalis
Pages 3-22
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Essential Concepts in Molecular Biology
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Molecular Themes in Oncogenesis
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- James N. Welch, Susan A. Chrysogelos
Pages 65-79
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- Kara N. Smolinski, Stephen J. Meltzer
Pages 81-111
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Mechanisms of Mutation
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Front Matter
Pages 113-113
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- William B. Coleman, Gregory J. Tsongalis
Pages 115-142
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- Takashi Shimamoto, Kazuma Ohyashiki
Pages 143-158
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- Bruce M. Boman, Lael Melchert, Jeremy Z. Fields
Pages 159-185
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Etiology of Human Cancers
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Front Matter
Pages 187-187
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- Lorenzo Tomatis, James Huff
Pages 189-201
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- Edward L. Loechler, Bryan Henry, Kwang-Young Seo
Pages 203-222
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- Cynthia R. Timblin, Yvonne Janssen-Heininger, Brooke T. Mossman
Pages 223-232
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- Felix Hoppe-Seyler, Karin Butz
Pages 233-247
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Human Tumor Systems
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Front Matter
Pages 249-249
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- J. Milburn Jessup, Gary Gallick, Bo Liu
Pages 251-268
About this book
Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.
Reviews
"The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies....The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced....the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." - Annals of Oncology
"This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." -Quarterly Review of Biology
Editors and Affiliations
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Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA
William B. Coleman
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Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA
Gregory J. Tsongalis