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Physical Agents in Human Carcinogenesis

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The Molecular Basis of Human Cancer

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Abstract

Since the original observations of Brand and Stanton (1) in which plastics and other solid materials implanted under the skin of rodents induced sarcomas, the concept of foreign body carcinogenesis has been viable and intriguing. The development of human lung cancers and mesotheliomas after exposure to insoluble particulates such as asbestos fibers has strengthened the argument that physical carcinogenesis is of importance in occupational and environmental settings. Crystalline silica has recently been classified as a carcinogen in humans (2). However, despite intense research efforts, diverse theories on mechanisms of physical carcinogenesis exist, and the molecular basis for these malignancies is slowly being unraveled. In this chapter, we will focus on the physical agents asbestos and silica, first addressing the epidemiology of these inhaled pollutants, and secondly emphasizing recent cellular and molecular data from our laboratory and others. Lastly, we will discuss how this information has contributed to an understanding of the pathogenesis of lung cancer and mesothelioma and the design of potential therapeutic strategies.

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Authors
  1. Cynthia R. Timblin PhD
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  2. Yvonne Janssen-Heininger PhD
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  3. Brooke T. Mossman PhD
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    William B. Coleman

  2. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Gregory J. Tsongalis

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Timblin, C.R., Janssen-Heininger, Y., Mossman, B.T. (2002). Physical Agents in Human Carcinogenesis. In: Coleman, W.B., Tsongalis, G.J. (eds) The Molecular Basis of Human Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-125-1_11

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