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Cellular Responses to Chemical Carcinogens

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The Molecular Basis of Human Cancer

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Abstract

Cancer is the second leading cause of death in the United States. It i s estimated that approximately a third of all Americans will develop cancer in their lifetime. The American Cancer Society estimated that 1,220,000 new cases of cancer and 550,000 deaths occurred in 2000 (see www.cancer.org). Agents that can cause cancer are called carcinogens. Carcinogens can be classified into agents that are chemical, viral, or physical (radiation such as untraviolet [UV] light, X-rays, and gamma rays). Approximately 60–90% of all cancers are now generally believed to be due to these environmental factors to which humans are exposed in food, water, or air. It is important to mention that the term environmental factors includes both natural and human-made agents.

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Authors
  1. Edward L. Loechler PhD
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  2. Bryan Henry PhD
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  3. Kwang-Young Seo PhD
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    William B. Coleman

  2. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Gregory J. Tsongalis

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Loechler, E.L., Henry, B., Seo, KY. (2002). Cellular Responses to Chemical Carcinogens. In: Coleman, W.B., Tsongalis, G.J. (eds) The Molecular Basis of Human Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-125-1_10

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  • DOI: https://doi.org/10.1007/978-1-59259-125-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-107-3

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