Teratogenicity Testing

Methods and Protocols

  • Luís Félix

Part of the Methods in Molecular Biology book series (MIMB, volume 1797)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction to Teratology Testing

    1. Front Matter
      Pages 1-1
    2. Ana M. Calado, Maria dos Anjos Pires
      Pages 3-32
    3. Sofia Alves-Pimenta, Luís Félix, Bruno Colaço, Paula A. Oliveira, Carlos Venâncio
      Pages 33-59
    4. Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira, Carlos Venâncio
      Pages 61-93
  3. In Vitro-Based Teratology Screening

    1. Front Matter
      Pages 95-95
    2. Lauren M. Walker, Darcie L. V. McClelland-Descalzo, Nicole I. zur Nieden
      Pages 97-124
    3. Joseph V. Madrid, Steven R. Sera, Nicole R. L. Sparks, Nicole I. zur Nieden
      Pages 125-145
    4. Wasay Mohiuddin Shaikh Qureshi, Margaret K. Pratten
      Pages 147-163
    5. Valéria Maria Lara, Kelly C. Santos Roballo, André Tadeu Gotardo, Carlos Eduardo Ambrósio
      Pages 165-175
  4. Animal-Based Teratology Methods

    1. Front Matter
      Pages 215-215
    2. Matheus C. Bianchini, José L. R. Portela, Robson L. Puntel, Daiana S. Ávila
      Pages 243-276
    3. Monalisa Mishra, Bedanta Kumar Barik
      Pages 277-298
    4. Hariz Islas-Flores, Itzayana Pérez-Alvaréz, Leobardo M. Gómez-Oliván
      Pages 299-307

About this book


This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.


Teratology Embryo-fetal development Developmental biology Drug exposure Toxicity Organogenesis Fetotoxic effects Animal models Pharmaceuticals

Editors and affiliations

  • Luís Félix
    • 1
  1. 1.Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB)University of Trás-os-Montes e Alto Douro (UTAD)Vila RealPortugal

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-7883-0
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7882-3
  • Online ISBN 978-1-4939-7883-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods