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Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans

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Book cover Teratogenicity Testing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1797))

Abstract

Environmental toxicants, chemical substances produced or introduced into the environment directly by humans or their activities, can act as teratogens during development that negatively impact health. Long-term ramifications of environmental exposures to sublethal doses of teratogens are often unrecognized and unknown. The round worm, Caenorhabditis elegans, is an emerging model organism to investigate the long-term impacts of environmental teratogens upon health. This chapter describes a toxicant exposure paradigm integrated with phenotyping assays to screen adult worms, and their progeny, for effects on reproduction, growth and development, behavior, and energy balance.

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Authors and Affiliations

  1. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

    Caralina Marín de Evsikova

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  1. Caralina Marín de Evsikova
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Correspondence to Caralina Marín de Evsikova .

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Editors and Affiliations

  1. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal

    Luís Félix

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Marín de Evsikova, C. (2018). Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans . In: Félix, L. (eds) Teratogenicity Testing. Methods in Molecular Biology, vol 1797. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7883-0_11

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  • DOI: https://doi.org/10.1007/978-1-4939-7883-0_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7882-3

  • Online ISBN: 978-1-4939-7883-0

  • eBook Packages: Springer Protocols

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