Abstract
Environmental toxicants, chemical substances produced or introduced into the environment directly by humans or their activities, can act as teratogens during development that negatively impact health. Long-term ramifications of environmental exposures to sublethal doses of teratogens are often unrecognized and unknown. The round worm, Caenorhabditis elegans, is an emerging model organism to investigate the long-term impacts of environmental teratogens upon health. This chapter describes a toxicant exposure paradigm integrated with phenotyping assays to screen adult worms, and their progeny, for effects on reproduction, growth and development, behavior, and energy balance.
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Marín de Evsikova, C. (2018). Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans . In: Félix, L. (eds) Teratogenicity Testing. Methods in Molecular Biology, vol 1797. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7883-0_11
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DOI: https://doi.org/10.1007/978-1-4939-7883-0_11
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