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  • © 1994

Toxin-Induced Models of Neurological Disorders

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  • ISBN: 978-1-4899-1447-7
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Softcover Book USD 149.99
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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xxi
  2. Animal Models and the Implications of Their Use

    • Arthur J. Nonneman, Michael L. Woodruff
    Pages 1-15
  3. Strategies for Developing Animal Models of Neurotoxicant-Induced Neurodegenerative Disorders

    • Paul R. Solomon, Maryellen Groccia-Ellison, Mark E. Stanton, William W. Pendlebury
    Pages 17-38
  4. Experimental Paradigms of Motor Neuron Degeneration

    • Michael J. Strong, Ralph M. Garruto
    Pages 39-88
  5. MPTP-Treated Mice: A Useful Model for Parkinson’s Disease?

    • Erik Sundström, Bengt G. Henriksson, Abdul H. Mohammed, Frédéric Souverbie
    Pages 121-137
  6. Behavioral Effects of MPTP Administration in the Vervet Monkey

    • J. R. Taylor, J. D. Elsworth, R. H. Roth, J. R. Sladek Jr., D. E. Redmond Jr.
    Pages 139-174
  7. Intranigral Iron Infusion as a Model for Parkinson’s Disease

    • G. W. Arendash, G. J. Sengstock, C. W. Olanow, S. Barone Jr., A. J. Dunn
    Pages 175-212
  8. Excitotoxic Lesions of the Neostriatum as an Animal Model of Huntington’s Disease

    • Dwaine F. Emerich, David W. Cahill, Paul R. Sanberg
    Pages 213-257
  9. Perinatal Intake of Polychlorinated Biphenyl (PCB)

    • Laura M. Juárez De Ku, Lee A. Meserve
    Pages 281-299
  10. Back Matter

    Pages 337-344

About this book

Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro­ toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni­ tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen­ cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro­ biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro­ degenerative disorders and assessing risk factors associated with neurotoxin ex­ posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.

Keywords

  • Alzheimer
  • Parkinson
  • dopamine
  • neurons
  • neuroscience
  • neurotoxicity

Editors and Affiliations

  • East Tennesee State University, Johnson City, USA

    Michael L. Woodruff

  • Asbury College, Wilmore, USA

    Arthur J. Nonneman

Bibliographic Information

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4899-1447-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 149.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)