Abstract
A motor neuron, by strict definition, is any neuron that functionally innervates a muscle fiber. In common usage, however, this term refers to both the supraspinal descending neurons of the motor pathways (upper motor neurons, UMN) and lower motor neurons (LMN). By analogy, the term motor neuron degeneration does not imply a disease state or process restricted to a single motor pathway. Because the manifestations of motor neuron degeneration, whether UMN or LMN, are ultimately governed by the motor unit consisting of the alpha motor neuron, its axon, and muscle fibers, only a limited repertoire of clinical phenomenology is possible for a relatively broad group of degenerative or toxic states. Therefore, in designing paradigms of motor neuron degeneration, it is important to differentiate among those degenerative processes that can affect upper or lower motor neurons selectively or in a combination, and yet still yield relatively similar disease states.
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Strong, M.J., Garruto, R.M. (1994). Experimental Paradigms of Motor Neuron Degeneration. In: Woodruff, M.L., Nonneman, A.J. (eds) Toxin-Induced Models of Neurological Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1447-7_3
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