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6-Hydroxydopamine Lesions of Nigrostriatal Neurons as an Animal Model of Parkinson’s Disease

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Toxin-Induced Models of Neurological Disorders

Abstract

Parkinson’s disease (PD) is a uniquely human affliction that profoundly affects all aspects of daily living as it progresses. In addition to the obvious and characteristic physical disability the sufferer displays to an outside observer, it is becoming increasingly evident that the inner worlds of emotion and thought can also be devastated during the advance of the disease.

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  1. Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, England

    Paul J. Reading & Stephen B. Dunnett

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    Michael L. Woodruff

  2. Asbury College, Wilmore, Kentucky, USA

    Arthur J. Nonneman

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Reading, P.J., Dunnett, S.B. (1994). 6-Hydroxydopamine Lesions of Nigrostriatal Neurons as an Animal Model of Parkinson’s Disease. In: Woodruff, M.L., Nonneman, A.J. (eds) Toxin-Induced Models of Neurological Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1447-7_4

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